Summary

Name RPS6KA4
Full Name Ribosomal protein S6 kinase alpha-4
Synonyms S6K-alpha-4, 90 kDa ribosomal protein S6 kinase 4, Nuclear mitogen- and stress-activated protein kinase 2, Ribosomal protein kinase B, RSKB | MSK2
Primary ID O75676
Links - -
Type protein
Relations 23
Function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation H3-4 0.2
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.58
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation RELA 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.403
Publications: 3 Organism: Homo Sapiens,
+ up-regulates activity img/direct-activation.png phosphorylation ATF1 0.596
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation HMGN1 0.342
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png TP53 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.561
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ATF1 0.596
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RPS6KA4 0.2
Publications: 1 Organism: Homo Sapiens