Relation Results

Summary

Name RPS6KA4
Full Name Ribosomal protein S6 kinase alpha-4
Synonyms S6K-alpha-4, 90 kDa ribosomal protein S6 kinase 4, Nuclear mitogen- and stress-activated protein kinase 2, Ribosomal protein kinase B, RSKB | MSK2
Primary ID O75676
Links - -
Type protein
Relations 25
Function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for ...
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Type: Score: Layout: SPV 
0.20.5950.20.5930.2740.2830.3970.6050.3390.5740.2510.2770.20.2RPS6KA4H3-4CREB1MAPK14RELACSNK2A1FOSATF1HMGN1MAPK3TP53NfKb-p65/p50Histone H3CD3G

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ RPS6KA4 img/unknown.png phosphorylation H3-4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-249211 Ser11 TKQTARKsTGGKAPR Mus musculus
pmid sentence
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28
Identifier Residue Sequence Organism Cell Line
SIGNOR-249212 Ser29 ATKVARKsAPATGGV Mus musculus
pmid sentence
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28
Publications: 2 Organism: Mus Musculus
+ RPS6KA4up-regulates img/direct-activation.png phosphorylation CREB1 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-157158 Ser119 EILSRRPsYRKILND Homo sapiens T-lymphocyte
pmid sentence
Msk1 and msk2 directly phosphorilate and activete transcription factors such as creb1, atf1 msk was the kinase responsible for phosphorylation of the transcription factor creb in response to tcr stimulation.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA4up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-154324 Ser196 EEKERTFsFCGTIEY Homo sapiens
pmid sentence
Ser-343 and ser-196 are autophosphorylated by the c-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the n-terminal kinase domain.
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ MAPK14up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.593
Identifier Residue Sequence Organism Cell Line
SIGNOR-77204 Ser196 EEKERTFsFCGTIEY Homo sapiens HeLa Cell
pmid sentence
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-77208 Ser343 TRLEPVYsPPGSPPP Homo sapiens HeLa Cell
pmid sentence
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-77212 Ser347 PVYSPPGsPPPGDPR Homo sapiens HeLa Cell
pmid sentence
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-77216 Ser360 PRIFQGYsFVAPSIL Homo sapiens HeLa Cell
pmid sentence
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-77220 Thr568 SPGVPMQtPCFTLQY Homo sapiens HeLa Cell
pmid sentence
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-60995 Homo sapiens
pmid sentence
Rsk-b is a p38alphamapk substrate, and activated by p38alphamapk and, more weakly, by erk1
Publications: 6 Organism: Homo Sapiens
+ RPS6KA4up-regulates activity img/direct-activation.png phosphorylation RPS6KA4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276269 Ser196 EEKERTFsFCGTIEY Homo sapiens HEK-293T Cell
pmid sentence
Here we report that the CK2 protein kinase, which contributes to NF-kappaB activation following UV radiation in a p38-dependent manner, physically interacts with MSK2 but not MSK1 and that CK2 inhibition specifically impairs UV-induced MSK2 kinase activation. A putative site of CK2 phosphorylation was mapped to MSK2 residue Ser(324) and when substituted to alanine (S324A) also compromised MSK2 activity.Serine 324 is required for UV-induced MSK2 activation and for autophosphorylation at MSK2-Ser196.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA4up-regulates img/direct-activation.png phosphorylation RELA 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-151436 Ser276 SMQLRRPsDRELSEP Homo sapiens
pmid sentence
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) msk 1 and 2 can directly phosphorylate and activate transcription factors such as creb, atf1, the nf-kb isoform p65 and stat 1 and 3.
Publications: 1 Organism: Homo Sapiens
+ CSNK2A1up-regulates activity img/direct-activation.png phosphorylation RPS6KA4 0.283
Identifier Residue Sequence Organism Cell Line
SIGNOR-276268 Ser324 PFRPQIRsELDVGNF Homo sapiens HEK-293T Cell
pmid sentence
Here we report that the CK2 protein kinase, which contributes to NF-kappaB activation following UV radiation in a p38-dependent manner, physically interacts with MSK2 but not MSK1 and that CK2 inhibition specifically impairs UV-induced MSK2 kinase activation. A putative site of CK2 phosphorylation was mapped to MSK2 residue Ser(324) and when substituted to alanine (S324A) also compromised MSK2 activity.Serine 324 is required for UV-induced MSK2 activation and for autophosphorylation at MSK2-Ser196.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA4up-regulates activity img/direct-activation.png phosphorylation FOS 0.397
Identifier Residue Sequence Organism Cell Line
SIGNOR-191678 Ser362 AAAHRKGsSSNEPSS Homo sapiens
pmid sentence
Rsk1/2 stabilize c-fos and increases its activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-37216 Ser362 AAAHRKGsSSNEPSS Homo sapiens
pmid sentence
Rsk1/2 phosphorylates the transcription factor c-fos on s362 and increases its activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263000 Ser374 PSSDSLSsPTLLAL
pmid sentence
Serine 374 and serine 362 are the primary sites targeted by Erk1/2 and the mitogen-activated protein kinase-activated kinases Rsk1/2 (12, 13, 37, 38, 41), respectively. Their phosphorylation leads to protein stabilization (3, 13, 20, 41). Threonine 325 and threonine 331 are secondary targets of Erk1/2; their modification occurs only when serines 362 and 374 are phosphorylated and Erk1/2 activation is sufficiently sustained (37, 38). This enhances the transcriptional activity of c-Fos
Publications: 3 Organism: Homo Sapiens,
+ RPS6KA4up-regulates activity img/direct-activation.png phosphorylation ATF1 0.605
Identifier Residue Sequence Organism Cell Line
SIGNOR-249145 Ser63 GILARRPsYRKILKD Mus musculus Fibroblast
pmid sentence
Using embryonic fibroblasts derived from these mice we were able to demonstrate an important role for these enzymes in the activation of CREB and the closely related transcription factor ATF1. | Our results clearly demonstrate that MSK1 and MSK2 are the major, if not the only, protein kinases that mediate the phosphorylation of CREB at Ser133 and of ATF1 at Ser63 in fibroblasts
Publications: 1 Organism: Mus Musculus
+ RPS6KA4 img/unknown.png phosphorylation HMGN1 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-249216 Ser7 sSAEGAAK Mus musculus Fibroblast
pmid sentence
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28 and HMG-14 at Ser6 after stimulation of primary embryonic fibroblasts by TPA or anisomycin.
Publications: 1 Organism: Mus Musculus
+ MAPK3up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.574
Identifier Residue Sequence Organism Cell Line
SIGNOR-60998 Homo sapiens
pmid sentence
Rsk-b is a p38alphamapk substrate, and activated by p38alphamapk and, more weakly, by erk1
Publications: 1 Organism: Homo Sapiens
+ RPS6KA4down-regulates img/indirect_inhibition.png TP53 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-188334 Homo sapiens
pmid sentence
Mitogen- and stress-activated kinase 2 (msk2) inhibits the transcription factor p53, and we investigate here the mechanisms underlying this inhibition. In the absence of stress stimuli, msk2 selectively suppressed the expression of a subset of p53 target genes.Msk2 can also control the the transcriptional activity of p53 in a kinase-indipendent mannermsk2 can also control the the transcriptional activity of p53 in a kinase-indipendent manner
Publications: 1 Organism: Homo Sapiens
+ RPS6KA4up-regulates img/direct-activation.png phosphorylation ATF1 0.605
Identifier Residue Sequence Organism Cell Line
SIGNOR-166661 Homo sapiens
pmid sentence
Msk1 and msk2 directly phosphorilate and activate transcription factors such as creb1, atf1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-116252 Homo sapiens
pmid sentence
Msk1 and msk2 directly phosphorilate and activate transcription factors such as creb1, atf1.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA4up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.277
Identifier Residue Sequence Organism Cell Line
SIGNOR-217373 Homo sapiens
pmid sentence
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) msk 1 and 2 can directly phosphorylate and activate transcription factors such as creb, atf1, the nf-kb isoform p65 and stat 1 and 3.
Publications: 1 Organism: Homo Sapiens
+ RPS6KA4 img/unknown.png phosphorylation Histone H3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265355 Mus musculus
pmid sentence
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28
Publications: 1 Organism: Mus Musculus
+ CD3Gup-regulates img/indirect-activation.png RPS6KA4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-157148 Homo sapiens T-lymphocyte
pmid sentence
Tcr stimulation also activates the mitogen- and stress-activated kinases (msk) downstream of erk1/2.
Publications: 1 Organism: Homo Sapiens
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