| + |
RIMS1 | up-regulates activity 
relocalization
|
RAB3A |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264381 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
RIMS2 | up-regulates activity
relocalization
|
RAB3A |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264377 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RABGGTA | up-regulates activity
lipidation
|
RAB3A |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265574 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18532927 |
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab proteins. Rab GTPases need to be geranylgeranylated on either one or two cysteine residues in their Ctermini in order to localize to the correct intracellular membrane and be functional |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2RL1 | up-regulates quantity by expression 
transcriptional regulation
|
RAB3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254836 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2R | up-regulates quantity by expression
transcriptional regulation
|
RAB3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254845 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21072196 |
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SYN1 | up-regulates activity
binding
|
RAB3A |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269181 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15265865 |
Synapsins, a family of neuron-specific phosphoproteins, have been demonstrated to regulate the availability of synaptic vesicles for exocytosis by binding to both synaptic vesicles and the actin cytoskeleton in a phosphorylation-dependent manner. The interaction between synapsin I and Rab3A was confirmed by photoaffinity labeling experiments on purified synaptic vesicles and by the formation of a chemically cross-linked complex between synapsin I and Rab3A in intact nerve terminals. The data indicate that synapsin I is a novel Rab3 interactor on synaptic vesicles and suggest that the synapsin-Rab3 interaction may participate in the regulation of synaptic vesicle trafficking within the nerve terminals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
RAB3A | up-regulates
|
Dense-core_vesicle_exocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31679900 |
Here, we identify the SEC4 ortholog RAB3 and its neuronal effector, RIM1, as essential molecules for neuropeptide and neurotrophin release from dense-core vesicles (DCVs) in mammalian neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
RAB3GAP1 | down-regulates activity 
gtpase-activating protein
|
RAB3A |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265580 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11809763 |
Rab3A, a member of the Rab3 small G protein family, regulates Ca(2+)-dependent exocytosis of neurotransmitter. The cyclical activation and inactivation of Rab3A are essential for the Rab3A action in exocytosis. GDP-Rab3A is activated to GTP-Rab3A by Rab3 GDP/GTP exchange protein (Rab3 GEP), and GTP-Rab3A is inactivated to GDP-Rab3A by Rab3 GTPase-activating protein (Rab3 GAP). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Brain |
| + |
RIMS3 | up-regulates activity
relocalization
|
RAB3A |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264379 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31679900 |
N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MADD | up-regulates activity
guanine nucleotide exchange factor
|
RAB3A |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265579 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11809763 |
Rab3A, a member of the Rab3 small G protein family, regulates Ca(2+)-dependent exocytosis of neurotransmitter. The cyclical activation and inactivation of Rab3A are essential for the Rab3A action in exocytosis. GDP-Rab3A is activated to GTP-Rab3A by Rab3 GDP/GTP exchange protein (Rab3 GEP), and GTP-Rab3A is inactivated to GDP-Rab3A by Rab3 GTPase-activating protein (Rab3 GAP). |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Brain |
| + |
RABGGTB | up-regulates activity
lipidation
|
RAB3A |
0.639 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265575 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18532927 |
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab proteins. Rab GTPases need to be geranylgeranylated on either one or two cysteine residues in their Ctermini in order to localize to the correct intracellular membrane and be functional |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RAB3A
- 
- 