3.0
FAP: Adipogenic transcriptional cascade
Pathway ID: SIGNOR-FapATC
Description: Adipocyte differentiation is a highly orchestrated process. The best understood regulators of adipogenesis are the transcription factors that inhibit or promote this process. To date, over two dozen transcription factors have been shown to play a role in adipocyte development. While peroxisome proliferator-activated receptor gamma (PPARγ) is undoubtedly the most important transcriptional modulator of adipocyte development in all types of adipose tissue, members of the CCAAT/enhancer-binding protein, Krüppel-like transcription factor, signal transducer and activator of transcription, GATA, early B cell factor and interferon-regulatory factor families also regulate adipogenesis (Mota de Sa et al Compr Physiol. 2017 16;7(2):635-674).
Curated by: gcesareni
Description: Adipocyte differentiation is a highly orchestrated process. The best understood regulators of adipogenesis are the transcription factors that inhibit or promote this process. To date, over two dozen transcription factors have been shown to play a role in adipocyte development. While peroxisome proliferator-activated receptor gamma (PPARγ) is undoubtedly the most important transcriptional modulator of adipocyte development in all types of adipose tissue, members of the CCAAT/enhancer-binding protein, Krüppel-like transcription factor, signal transducer and activator of transcription, GATA, early B cell factor and interferon-regulatory factor families also regulate adipogenesis (Mota de Sa et al Compr Physiol. 2017 16;7(2):635-674).
Curated by: gcesareni
