| + |
E2F1 | up-regulates quantity by expression 
transcriptional regulation
|
DLK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271684 |
|
|
|
|
| pmid |
sentence |
| 19874716 |
Using luciferase reporter assay, ChIP assay and EMSA, we found that the -211/-194 region of the pref-1 promoter is essential for the binding of E2F1 as well as E2F1-dependent transcriptional activation. |
|
| Publications: |
1 |
| + |
DLK1 | down-regulates 
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254980 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 8500166 |
This indicates that pref-1 functions as a negative regulator of adipocyte differentiation, possibly in a manner analogous to EGF-like proteins that govern cell fate decisions in invertebrates. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197634 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22640926 |
We conclude that DLK1(PREF1) is well expressed in human ASC and acts as a negative regulator of adipogenesis. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | FAP: Insulin-mediated adipogenesis |
| + |
BMP7 | down-regulates quantity by repression
transcriptional regulation
|
DLK1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166426 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20584981 |
Bmp7 could directly suppress pref-1 expression, thereby allowing the initiation of the adipogenic program. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLK1 | up-regulates
binding
|
FN1 |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20457810 |
We show a direct interaction of pref-1 and fibronectin via the pref-1 juxtamembrane domain and fibronectin c-terminal domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXA2 | up-regulates quantity by expression
transcriptional regulation
|
DLK1 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254971 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12865419 |
Taken together, these data suggest that Foxa-2 is a direct transcriptional activator of the Pref-1 gene. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | FAP: Insulin-mediated adipogenesis |
| + |
KLF6 | down-regulates quantity by repression
transcriptional regulation
|
DLK1 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137836 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15917248 |
We have identified kr?ppel-like factor-6 (klf6), a recently described tumor suppressor gene, as a repressor of the proto-oncogene delta-like 1 (dlk1), a gene encoding a transmembrane protein that inhibits adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF6 | down-regulates
transcriptional regulation
|
DLK1 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210016 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15917248 |
We have identified krappel-like factor-6 (klf6), a recently described tumor suppressor gene, as a repressor of the proto-oncogene delta-like 1 (dlk1), a gene encoding a transmembrane protein that inhibits adipocyte differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLK1 | up-regulates 
transcriptional regulation
|
SOX9 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209968 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Pref-1 inhibits adipocyte differentiation through upregulating sox9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLK1 | down-regulates activity 
binding
|
NOTCH1 |
0.493 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172830 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 21419176 |
Moreover, the interaction of DLK1 with NOTCH1 caused an inhibition of basal NOTCH signaling in preadipocytes and mesenchymal multipotent cells. In this work, we demonstrate, for the first time, that DLK2 interacts with itself, with DLK1, and with the same NOTCH1 receptor region as DLK1 does. We demonstrate also that the interaction of DLK2 with NOTCH1 similarly results in an inhibition of NOTCH signaling in preadipocytes and Mouse Embryo fibloblasts. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
DLK1 | up-regulates quantity by expression
transcriptional regulation
|
SOX9 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Pref-1 inhibits adipocyte differentiation through upregulating sox9 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | down-regulates
transcriptional regulation
|
DLK1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210074 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20584981 |
Bmp7 could directly suppress pref-1 expression, thereby allowing the initiation of the adipogenic program. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DLK1
- 
- 