| + |
TSC22D3 | down-regulates activity 
binding
|
NfKb-p65/p50 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253299 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11468175 |
GILZ inhibits NF-kappaB nuclear translocation and DNA binding due to a direct protein-to-protein interaction of GILZ with the NF-kappaB subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity by expression 
transcriptional regulation
|
TSC22D3 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255950 |
|
|
Mus musculus |
CTLL-2 Cell |
| pmid |
sentence |
| 15705665 |
We have analyzed the promoter of human gilz (glucocorticoid-induced leucine zipper), a dexamethasone-inducible gene that is involved in regulating apoptosis, and identified six glucocorticoid (GC)-responsive elements and three Forkhead responsive elements (FHREs). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CRTC2 | up-regulates quantity
transcriptional regulation
|
TSC22D3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256109 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
CRTC2 knockdown attenuates glucocorticoid-responsive GILZ mRNA expression in HeLa cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates activity
transcriptional regulation
|
TSC22D3 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256094 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15031210 |
We then characterized the human gilz promoter and showed that FoxO3 (Forkhead box class O3) binding to the Forkhead responsive elements identified in the promoter is necessary for induction of gilz expression upon IL-2 withdrawal |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TSC22D3 | down-regulates activity
binding
|
RELA |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253297 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11468175 |
GILZ inhibits NF-kappaB nuclear translocation and DNA binding due to a direct protein-to-protein interaction of GILZ with the NF-kappaB subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
relocalization
|
FOXO1 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256146 |
|
|
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 20018851 |
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
relocalization
|
FOXO |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269854 |
|
|
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 20018851 |
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
binding
|
NFKB2 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253298 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11468175 |
GILZ inhibits NF-kappaB nuclear translocation and DNA binding due to a direct protein-to-protein interaction of GILZ with the NF-kappaB subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates quantity by repression 
transcriptional regulation
|
PPARG |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253296 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 12671681 |
In this study, we showed that GILZ, which is transcriptionally induced by GCs, inhibits the transcription of the PPAR-γ2 gene and blocks adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NR3C1 | up-regulates quantity by expression 
transcriptional regulation
|
TSC22D3 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253295 |
|
|
Mus musculus |
Thymocyte |
| pmid |
sentence |
| 9430225 |
In thymocytes and peripheral T cells, GILZ gene expression is induced by DEX |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TSC22D3 | down-regulates activity
relocalization
|
FOXO4 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256148 |
|
|
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 20018851 |
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TSC22D3 | down-regulates activity
relocalization
|
FOXO3 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20018851 |
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TSC22D3
- 
- 