Summary

Name CENPE
Full Name Centromere-associated protein E
Synonyms Centromere protein E, CENP-E, Kinesin-7, Kinesin-related protein CENPE |
Primary ID Q02224
Links - -
Type protein
Relations 12
Function Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/indirect-activation.png CENPE 0.391
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Spindle_assembly 0.7
Publications: 1
+ up-regulates activity img/direct-activation.png binding CENPE 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CENPE 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CENPE 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BUB1B 0.84
Publications: 2 Organism: In Vitro, Mus Musculus
+ up-regulates activity img/indirect-activation.png MAD2L1 0.784
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png MAD1L1 0.617
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding CENPE 0.606
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CENPE 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png relocalization CENPE 0.824
Publications: 1