Summary

Name FZD5
Full Name Frizzled-5
Synonyms Fz-5, hFz5, FzE5 | C2orf31
Primary ID Q13467
Links - -
Type protein
Relations 10
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding FZD5 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD5 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP5 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CEBPA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPARG 0.14
Publications: 1 Organism: Homo Sapiens