| + |
CASP3 | down-regulates activity 
cleavage
|
PTCH1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104585 |
Asp1405 |
CPGYPETdHGLFEDP |
Homo sapiens |
|
| pmid |
sentence |
| 12907805 |
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates
cleavage
|
PTCH1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256437 |
Asp1405 |
CPGYPETdHGLFEDP |
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
PTCH1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256438 |
Asp1405 |
CPGYPETdHGLFEDP |
Homo sapiens |
|
| pmid |
sentence |
| 12907805 |
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP3 | down-regulates
cleavage
|
PTCH1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199111 |
Asp1405 |
CPGYPETdHGLFEDP |
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SHH | down-regulates activity
binding
|
PTCH1 |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14556242 |
In the responding cell, active Hedgehog binds to its receptor Patched, a 12-pass transmembrane protein, which frees Smoothened, an adjacent 7-pass transmembrane protein, for downstream signaling.Thus, a balance is created by the antagonism of Hedgehog and Patched, whose relative concentrations alternate with respect to each other. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-61552 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9811851 |
Biochemical analysis of ptch and ptch2 shows that they both bind to all hedgehog family members with similar affinity and that they can form a complex with smo.Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein Smoothened (SMO) by PTCH. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132675 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15618519 |
Binding of sonic hedgehog (shh) to patched (ptc) relieves the latter's tonic smoothened (smo), a receptor that spans the cell membrane seven times. .Ptch Exists in vertebrates as two isoforms, ptch1 and ptch2, which seem to be equivalent in terms of binding the three hh isoforms. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | Sonic Hedgehog |
| + |
GLI1 | up-regulates quantity by expression 
transcriptional regulation
|
PTCH1 |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188875 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
Gli activators bind to gaccaccca motif to regulate transcription of gli1, ptch1, ptch2, hhip1, mycn, ccnd1, ccnd2, bcl2, cflar, foxf1, foxl1, prdm1 (blimp1), jag2, grem1, and follistatin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209620 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
PTCH1 | down-regulates activity
binding
|
SMO |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14556242 |
In the responding cell, active Hedgehog binds to its receptor Patched, a 12-pass transmembrane protein, which frees Smoothened, an adjacent 7-pass transmembrane protein, for downstream signaling.Thus, a balance is created by the antagonism of Hedgehog and Patched, whose relative concentrations alternate with respect to each other. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91709 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12192414 |
We show that free Ptc (unbound by Hh) acts sub-stoichiometrically to suppress Smo activity and thus is critical in specifying the level of pathway activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Medulloblastoma Cell, Basal Cell Carcinoma Cell |
| Pathways: | Sonic Hedgehog |
| + |
GLI3 | up-regulates quantity by expression
transcriptional regulation
|
PTCH1 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209641 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17419683 |
Binding of n-shh to ptch1 inhibits repression of smo, leading to activationof some genes and de-repression of others through the effects of smo on the gli family of transcription factors. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
PTCH1 | up-regulates 
binding
|
CCNB1 |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331587 |
In addition, we demonstrate that endogenous ptc1 and endogenous cyclin B1 interact in vivo. The findings reported here demonstrate that ptc1 participates in determining the subcellular localization of cyclin B1 and suggest a link between the tumor suppressor activity of ptc1 and the regulation of cell division. Thus, we propose that ptc1 participates in a G2/M checkpoint by regulating the localization of MPF. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRP2 | up-regulates quantity
binding
|
PTCH1 |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26872844 |
LRP2 Promotes SHH Activity in Neurogenic Niches of the Developing and Adult Brain. In the RDVM, LRP2 forms a co-receptor complex with PTCH1 facilitating SHH binding and internalization of SHH/PTCH1 complexes, a prerequisite for pathway activation (Fig. 3B). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
GLI3 | up-regulates quantity by expression
transcriptional regulation
|
PTCH1 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19860666 |
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
PTCH1 | form complex 
binding
|
CDON/BOC/PTCH1 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209602 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21664576 |
Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1). However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1, CDO, and BOC, as putative coreceptors for HH ligands. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GPC6 | up-regulates activity
binding
|
PTCH1 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31756413 |
Based on results from in vitro experiments, we had previously proposed that GPC6 stimulates Hh signaling by interacting with Hh and Patched1 (Ptc1), and facilitating/stabilizing their interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Yellow AB | down-regulates
chemical inhibition
|
PTCH1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158650 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17970037 |
Anti-patched-1 antibodies suppress hedgehog signaling pathway and pancreatic cancer proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLITRK5 | down-regulates activity
binding
|
PTCH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268438 |
|
|
Mus musculus |
Osteoblast |
| pmid |
sentence |
| 34326333 |
SLITRK5 interacts with SHH and PTCH1. Mechanistically, SLITRK5 binds to hedgehog ligands via its extracellular domain and interacts with PTCH1 via its intracellular domain. SLITRK5 is present in the primary cilium, and loss of SLITRK5 enhances SMO ciliary enrichment upon SHH stimulation. Thus, SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts that may be attractive as a therapeutic target to enhance bone formation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GLI2 | up-regulates quantity by expression
transcriptional regulation
|
PTCH1 |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209632 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
IHH | down-regulates activity
binding
|
PTCH1 |
0.833 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-61311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9811851 |
Biochemical analysis of ptch and ptch2 shows that they both bind to all hedgehog family members with similar affinity and that they can form a complex with smo.Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein Smoothened (SMO) by PTCH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | Sonic Hedgehog |
3.0
PTCH1
- 
- 