| + |
NR0B2 | down-regulates quantity by repression 
transcriptional regulation
|
HNF4A |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10594021 |
Here we show that shp inhibits transactivation by the orphan receptor hepatocyte nuclear factor 4 (hnf-4) and the retinoid x receptor (rxr) by at least two mechanisms shp also competes with coactivators for binding to ligand-activated rxr, and based on the ligand-dependent interaction with other nuclear receptors, it is likely that coactivator competition is a general feature of shp-mediated repression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | up-regulates quantity by expression 
transcriptional regulation
|
G6P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267791 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270256 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates 
binding
|
AR |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11735420 |
We demonstrated that shp inhibited both ar-lbd and ntd-dependent transactivation, which evidenced for the first time a protein capable of inhibiting a steroid receptor amino-terminal-dependent transactivation. We further characterized the shp mechanism of action by showing that shp reversed ar coactivator-mediated activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates
binding
|
NR1I3 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123154 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15000748 |
The short heterodimer partner (shp), an orphan nuclear receptor that lacks a conventional dna binding domain, was initially identified by its interaction with car. We have examined the role of shp in car-mediated transactivation of the cyp2b gene. Coexpression of shp inhibited the transactivation of the cyp2b gene by car in cultured hepatoma cells and the p160 coactivator grip1 reversed the inhibition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | up-regulates 
binding
|
PPARA |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11369442 |
Surprisingly, shp potentiated transcription by pparalpha/rxralpha heterodimers from the hd-ppre. This is the first demonstration of positive transcriptional activity attributable to shp. Together, these results suggest that shp can modulate pparalpha/rxralpha-mediated transcription in a response element-specific manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates activity
binding
|
CEBPA |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254831 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17094771 |
SHP repressed C/EBPalpha (CCAAT/enhancer-binding protein alpha)-driven transcription of PEPCK through direct interaction with C/EBPalpha protein both in vitro and in vivo. The formation of an active transcriptional complex of C/EBPalpha and its binding to DNA was inhibited by SHP, resulting in the inhibition of PEPCK gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates
binding
|
NR5A2 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134202 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15723037 |
Modulation of human nuclear receptor lrh-1 activity by phospholipids and shpthe human nuclear receptor liver receptor homolog 1 (hlrh-1) plays an important role in the development of breast carcinomas. This orphan receptor is efficiently downregulated by the unusual co-repressor shp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-92060 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12198243 |
Here we show that shp can interact with the liver x receptors lxralpha (nr1h3) and lxrbeta (nr1h2), as demonstrated by glutathione-s-transferase pull-down assays, mammalian two-hybrid, and coimmunoprecipitation experiments. In transfection assays, shp inhibits the expression of an artificial reporter driven by an lxr-response element and represses the transcriptional activation by lxr of the human atp-binding cassette transporter 1 (abca1) promoter |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
NR1H2 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91901 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 12198243 |
Here we show that shp can interact with the liver x receptors lxr? (nr1h3) and lxr? (nr1h2), as demonstrated by glutathione-s-transferase pull-down assays, mammalian two-hybrid, and coimmunoprecipitation experiments. In transfection assays, shp inhibits the expression of an artificial reporter driven by an lxr-response element and represses the transcriptional activation by lxr of the human atp-binding cassette transporter 1 (abca1) promoter. T |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | up-regulates quantity by expression
transcriptional regulation
|
G6PC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158065 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
NR1H3 |
0.467 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91996 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 12198243 |
Here we show that shp can interact with the liver x receptors lxr? (nr1h3) and lxr? (nr1h2), as demonstrated by glutathione-s-transferase pull-down assays, mammalian two-hybrid, and coimmunoprecipitation experiments. In transfection assays, shp inhibits the expression of an artificial reporter driven by an lxr-response element and represses the transcriptional activation by lxr of the human atp-binding cassette transporter 1 (abca1) promoter. T |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
PCK2 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254832 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17094771 |
SHP repressed C/EBPalpha (CCAAT/enhancer-binding protein alpha)-driven transcription of PEPCK through direct interaction with C/EBPalpha protein both in vitro and in vivo. The formation of an active transcriptional complex of C/EBPalpha and its binding to DNA was inhibited by SHP, resulting in the inhibition of PEPCK gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
THRA |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108248 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11368516 |
Shp (short heterodimer partner) is an orphan nuclear receptor lacking a dna binding domain that interacts with nuclear receptors (nr) including thyroid receptor (tr), retinoic acid receptors (rar and rxr), and estrogen receptors alpha and beta (eralpha and erbeta). Shp acts as a negative regulator of these receptors by inhibiting dna binding and transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates
binding
|
ESR1 |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115033 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11861507 |
Our results identify shp as an inhibitor of 4-oht agonist activity in rl95-2 human endometrial carcinoma cells that express endogenous er?. We conclude that shp does not decrease er expression, but rather it is the direct interaction of shp with er that inhibits er transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
ESR2 |
0.639 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74291 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10648597 |
These novel insights provide a mechanistic explanation for the inhibitory role of shp in nuclear receptor signaling, and they may explain how shp functions as a negative coregulator or corepressor for ligand-activated receptors, a novel and unique function for an orphan nuclear receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
ESRRG |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111620 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11705994 |
The current study also demonstrates that shp inhibits err_ transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESR1 | down-regulates quantity by repression
transcriptional regulation
|
NR0B2 |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10648597 |
We demonstrate that shp variants, carrying either interaction-defective nr box mutations or a deletion of the repressor domain, have lost the capacity to inhibit agonist-dependent transcriptional estrogen receptor activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
metformin | up-regulates quantity by expression
|
NR0B2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates
|
NR0B2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17909097 |
We have concluded that metformin inhibits hepatic gluconeogenesis through ampk-dependent regulation of shp |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR0B2 | down-regulates quantity by repression
transcriptional regulation
|
THR |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270298 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11368516 |
Shp (short heterodimer partner) is an orphan nuclear receptor lacking a dna binding domain that interacts with nuclear receptors (nr) including thyroid receptor (tr), retinoic acid receptors (rar and rxr), and estrogen receptors alpha and beta (eralpha and erbeta). Shp acts as a negative regulator of these receptors by inhibiting dna binding and transcriptional activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267806 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11368516 |
Shp (short heterodimer partner) is an orphan nuclear receptor lacking a dna binding domain that interacts with nuclear receptors (nr) including thyroid receptor (tr), retinoic acid receptors (rar and rxr), and estrogen receptors alpha and beta (eralpha and erbeta). Shp acts as a negative regulator of these receptors by inhibiting dna binding and transcriptional activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CLOCK | up-regulates quantity by expression
transcriptional regulation
|
NR0B2 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253698 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20674862 |
CLOCK knockdown activated MTP promoter and reduced small heterodimer partner (SHP, NROB2). CLOCK upregulated SHP by binding to its E box. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NR0B2 | down-regulates
binding
|
NR1I2 |
0.548 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101924 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12805410 |
Our results suggest that shp is a negative regulator of pxr transcriptional activity. This conclusion derives from_ in vitro, cell culture, and_ in vivo_ experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
NR0B2
- 
- 