| + |
LATS2 | up-regulates quantity by stabilization 
phosphorylation
|
AMOT |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275846 |
Ser175 |
QGHVRSLsERLMQMS |
|
|
| pmid |
sentence |
| 24101513 |
Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, ubiquitinate, and stabilize Amot130 |
|
| Publications: |
1 |
| + |
LATS1 | up-regulates quantity by stabilization
phosphorylation
|
AMOT |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275843 |
Ser175 |
QGHVRSLsERLMQMS |
|
|
| pmid |
sentence |
| 24101513 |
Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, ubiquitinate, and stabilize Amot130 |
|
| Publications: |
1 |
| + |
AMOT | down-regulates 
relocalization
|
YAP1 |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201135 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21205866 |
Our results indicate a potential tumor-suppressing role of AMOT family proteins as components of the Hippo pathway, and demonstrate a novel mechanism of YAP and TAZ inhibition by AMOT-mediated tight junction localization. These observations provide a potential link between the Hippo pathway and cell contact inhibition. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Yap/taz and angiomotin (amot) family proteins were shown to interact, resulting in yap/taz localization to tight junctions and inhibition through phosphorylation-dependent and -independent mechanisms. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AMOT | down-regulates activity
binding
|
YAP/TAZ |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277657 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21205866 |
AMOT inhibits YAP/TAZ by regulating YAP/TAZ localization via physical interaction and promoting YAP/TAZ phosphorylation by the Hippo pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP1 | up-regulates quantity by stabilization
ubiquitination
|
AMOT |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275847 |
|
|
|
|
| pmid |
sentence |
| 24101513 |
Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, ubiquitinate, and stabilize Amot130 |
|
| Publications: |
1 |
| + |
AMOT | down-regulates
relocalization
|
WWTR1 |
0.668 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175776 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21205866 |
Our results indicate a potential tumor-suppressing role of AMOT family proteins as components of the Hippo pathway, and demonstrate a novel mechanism of YAP and TAZ inhibition by AMOT-mediated tight junction localization. These observations provide a potential link between the Hippo pathway and cell contact inhibition. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201132 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Yap/taz and angiomotin (amot) family proteins were shown to interact, resulting in yap/taz localization to tight junctions and inhibition through phosphorylation-dependent and -independent mechanisms. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
AMOT
- 
- 