Summary

Name TICAM1
Full Name TIR domain-containing adapter molecule 1
Synonyms TICAM-1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, MyD88-3, TIR domain-containing adapter protein inducing IFN-beta | PRVTIRB, TRIF
Primary ID Q8IUC6
Links - -
Type protein
Relations 6
Pathways Toll like receptors, Macrophage polarization
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding TICAM1
Publications: 1 Organism: Mus Musculus
Pathways:Macrophage polarization
+ down-regulates img/direct_inhibition.png binding TICAM1
Publications: 1 Organism: Mus Musculus
Pathways:Toll like receptors
+ up-regulates activity img/direct-activation.png binding TICAM1
Publications: 1 Organism: Mus Musculus
Pathways:Toll like receptors
+ up-regulates activity img/direct-activation.png binding TICAM1 0.99
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Toll like receptors
+ up-regulates activity img/direct-activation.png binding TBK1 0.96
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ up-regulates activity img/direct-activation.png binding RIPK1 0.77
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization