Osteoblast: TGF beta

Pathway ID: SIGNOR-OsteoTGFB

Description: Transforming Growth Factors (TGFs) play opposite roles in osteogenic differentiation. SMAD-dependent pathway inhibits osteogenesis whereas SMAD-independent pathway (a MAPK signal transduction) activates osteogenic transcription factors, such as RUNX2, DLX5 and SP7, starting osteoblast differentiation.

Curated by: Giulio Giuliani

13 Seed Entities

Organism:
Name Primary ID
DLX5 P56178
MAP2K6 P52564
TGFB1 P01137
SP7 Q8TDD2
Osteoblast_differentiation SIGNOR-PH9
TRAF6 Q9Y4K3
MAP3K7 O43318
TGFBR2 P37173
RUNX2 Q13950
MAP2K3 P46734
MAPK14 Q16539
SMAD3 P84022
TGFBR1 P36897