Summary

Name GATA6
Full Name Transcription factor GATA-6
Synonyms GATA-binding factor 6 |
Primary ID Q92908
Links - -
Type protein
Relations 12
Function Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GATA6 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLXNA2 0.28
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SEMA3C 0.49
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA6
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA6 0.17
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png unknown MYC 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png unknown HES1 0.26
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png unknown RARB 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png unknown CDX2 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP11A1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP17A1 0.28
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary