Summary
| Name |  GATA6View Modifications |
| Full Name | Transcription factor GATA-6 |
| Synonyms | GATA-binding factor 6 | |
| Primary ID | Q92908 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GSK3A | down-regulates quantity by destabilization 
phosphorylation
|
GATA6 | 0.27 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GATA6 | up-regulates quantity by expression 
transcriptional regulation
|
PLXNA2 | 0.28 |
| Publications: | 1 | |||
| + | GATA6 | up-regulates quantity by expression
transcriptional regulation
|
SEMA3C | 0.49 |
| Publications: | 1 | |||
| + | POU5F1 | down-regulates quantity by repression 
transcriptional regulation
|
GATA6 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NANOG | down-regulates quantity by repression
transcriptional regulation
|
GATA6 | 0.17 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | GATA6 | up-regulates quantity by expression
unknown
|
MYC | 0.05 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GATA6 | up-regulates quantity by expression
unknown
|
HES1 | 0.26 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GATA6 | up-regulates quantity by expression
unknown
|
RARB | 0.16 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GATA6 | up-regulates quantity by expression
unknown
|
CDX2 | 0.11 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GATA6 | up-regulates quantity by expression
transcriptional regulation
|
CYP11A1 | 0.10 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GATA6 | up-regulates quantity by expression
transcriptional regulation
|
CYP17A1 | 0.28 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary | |||