Summary

Name GATA6
Full Name Transcription factor GATA-6
Synonyms GATA-binding factor 6 |
Primary ID Q92908
Links - -
Type protein
Relations 13
Function Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GATA6 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GATA6 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLXNA2 0.246
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA6 0.464
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png MYC 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png CDX2 0.461
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png RARB 0.293
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA6 0.483
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png HES1 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP17A1 0.348
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP11A1 0.327
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SEMA3C 0.401
Publications: 1