Relation Results

Summary

Name KAT5
Full Name Histone acetyltransferase KAT5
Synonyms 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein | HTATIP, TIP60
Primary ID Q92993
Links - -
Type protein
Relations 17
Pathways Acute Myeloid Leukemia, IDH-TET in AML
Function Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetyla ...
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Type: Score: Layout: SPV 
0.4240.20.20.7920.4780.4280.3750.490.6330.3720.6390.776KAT5NOTCH1H4C1CHKAATMSRSF2CyclinB/CDK1GSK3BCDK1ABL1MYOD1MDM2NuA4 complex

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ KAT5down-regulates img/direct_inhibition.png acetylation NOTCH1 0.424
Identifier Residue Sequence Organism Cell Line
SIGNOR-156911 Lys2029 NAVDDLGkSALHWAA Homo sapiens
pmid sentence
This result implies that the residues k2019, k2039, k2044, and k2068 of notch1-ic are the major targets of the acetyltransferase activity of tip60.
Identifier Residue Sequence Organism Cell Line
SIGNOR-156915 Lys2049 DAAVVLLkNGANKDM Homo sapiens
pmid sentence
This result implies that the residues k2019, k2039, k2044, and k2068 of notch1-ic are the major targets of the acetyltransferase activity of tip60.
Identifier Residue Sequence Organism Cell Line
SIGNOR-156919 Lys2054 LLKNGANkDMQNNRE Homo sapiens
pmid sentence
This result implies that the residues k2019, k2039, k2044, and k2068 of notch1-ic are the major targets of the acetyltransferase activity of tip60.
Identifier Residue Sequence Organism Cell Line
SIGNOR-156923 Lys2078 EGSYETAkVLLDHFA Homo sapiens
pmid sentence
This result implies that the residues k2019, k2039, k2044, and k2068 of notch1-ic are the major targets of the acetyltransferase activity of tip60.
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ KAT5down-regulates activity img/direct_inhibition.png acetylation H4C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262061 Lys21 GGAKRHRkVLRDNIQ Homo sapiens
pmid sentence
Thus, the TIP60 HAT complex is recruited to MYC-target genes and, probably with other other HATs, contributes to histone acetylation in response to mitogenic signals.
Publications: 1 Organism: Homo Sapiens
+ KAT5up-regulates activity img/direct-activation.png acetylation CHKA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267648 Lys247 MPFNKEPkWLFGTME Homo sapiens
pmid sentence
Glucose deprivation induces the binding of choline kinase α2 (CHKα2) to lipid droplets, followed by a continuous PTMs to promote lipolysis of lipid droplets, which are in turn mediated by AMPK-dependent CHKα2 Serine 279 phosphorylation and KAT5-dependent CHKα2 Lysine 247 acetylation.
Publications: 1 Organism: Homo Sapiens
+ KAT5up-regulates activity img/direct-activation.png acetylation ATM 0.792
Identifier Residue Sequence Organism Cell Line
SIGNOR-275891 Lys3016 VLMRLQEkLKGVEEG
pmid sentence
Here, we report that sirtuin 7 (SIRT7)-mediated deacetylation is essential for dephosphorylation and deactivation of ATM. We show that SIRT7, a class III histone deacetylase, interacts with and deacetylates ATM in vitro and in vivo. |Upon DNA damage, ATM is activated via a series of highly organized machineries, including acetylation by the histone acetyltransferase TIP60 at lysine 3016
Publications: 1
+ KAT5down-regulates img/direct_inhibition.png acetylation SRSF2 0.478
Identifier Residue Sequence Organism Cell Line
SIGNOR-170594 Lys52 IPRDRYTkESRGFAF Homo sapiens
pmid sentence
In this study, we provide the first evidence that the acetyltransferase tip60 acetylates srsf2 on its lysine 52 residue inside the rna recognition motif, and promotes its proteasomal degradation.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ CyclinB/CDK1up-regulates activity img/direct-activation.png phosphorylation KAT5 0.428
Identifier Residue Sequence Organism Cell Line
SIGNOR-250641 Ser86 TKNGLPGsRPGSPER Homo sapiens HeLa Cell
pmid sentence
Baculovirus-based expression and purification of Tip60 combined with mass spectrometry allowed the identification of serines 86 and 90 as two major sites of phosphorylation in vivo. The phosphorylation of Tip60 was found to modulate its histone acetyltransferase activity. One of the identified phosphorylated serines, Ser-90, was within a consensus cyclin B/Cdc2 site. Ser-90 was specifically phosphorylatedin vitro by the cyclin B/Cdc2 complex.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250642 Ser90 LPGSRPGsPEREVPA Homo sapiens HeLa Cell
pmid sentence
Baculovirus-based expression and purification of Tip60 combined with mass spectrometry allowed the identification of serines 86 and 90 as two major sites of phosphorylation in vivo. The phosphorylation of Tip60 was found to modulate its histone acetyltransferase activity. One of the identified phosphorylated serines, Ser-90, was within a consensus cyclin B/Cdc2 site. Ser-90 was specifically phosphorylatedin vitro by the cyclin B/Cdc2 complex.
Publications: 2 Organism: Homo Sapiens
+ GSK3Bup-regulates img/direct-activation.png phosphorylation KAT5 0.375
Identifier Residue Sequence Organism Cell Line
SIGNOR-174049 Ser86 TKNGLPGsRPGSPER Homo sapiens
pmid sentence
We demonstrate that gsk-3 phosphorylates serine 86 of the p53-acetyltransferase tip60. A tip60(s86a) mutant was less active to induce p53 k120 acetylation, histone 4 acetylation, and expression of puma
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ CDK1up-regulates img/direct-activation.png phosphorylation KAT5 0.49
Identifier Residue Sequence Organism Cell Line
SIGNOR-139649 Ser86 TKNGLPGsRPGSPER Homo sapiens
pmid sentence
Moreover, app stabilized tip60 through cdk-dependent phosphorylation
Identifier Residue Sequence Organism Cell Line
SIGNOR-139653 Ser90 LPGSRPGsPEREVPA Homo sapiens
pmid sentence
Moreover, app stabilized tip60 through cdk-dependent phosphorylation
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ ABL1down-regulates activity img/direct_inhibition.png phosphorylation KAT5 0.633
Identifier Residue Sequence Organism Cell Line
SIGNOR-276598 Tyr294 HPPGNEIyRKGTISF Homo sapiens HEK-293 Cell
pmid sentence
We present evidence that Tip60 is modified on tyrosine 327 by Abl kinase. We show that this causes functional changes in HAT activity and the subcellular localization of TIP60, which forms a complex with Abl kinase. The Tip60 mutation Y327F abolished tyrosine phosphorylation, reduced the inhibition of Tip60 HAT activity, and caused G0-G1 arrest and association with FE65. 
Publications: 1 Organism: Homo Sapiens
+ KAT5up-regulates activity img/direct-activation.png binding MYOD1 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-237675 Homo sapiens HEK-293 Cell
pmid sentence
Tip60 regulates myoblast differentiation by enhancing the transcriptional activity of MyoD via their physical interactions.
Publications: 1 Organism: Homo Sapiens
+ MDM2down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination KAT5 0.639
Identifier Residue Sequence Organism Cell Line
SIGNOR-272613 Homo sapiens U2-OS Cell
pmid sentence
Furthermore, we provide evidence that Mdm2, the ubiquitin ligase of the p53 tumour suppressor, interacts physically with Tip60 and induces its ubiquitylation and proteasome-dependent degradation.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ KAT5form complex img/form-complex.png binding NuA4 complex 0.776
Identifier Residue Sequence Organism Cell Line
SIGNOR-269297 Homo sapiens
pmid sentence
NuA4 (for nucleosome acetyltransferase of H4) is a 12-subunit HAT complex responsible for acetylation of histone H4 and H2A N-terminal tails.
Publications: 1 Organism: Homo Sapiens
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