Summary

Name TSC22D3
Full Name TSC22 domain family protein 3
Synonyms DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R | DSIPI, GILZ
Primary ID Q99576
Links - -
Type protein
Relations 12
Pathways FAP: Glucocorticoids, FAP: GCR-cAMP crosstalk
Function Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TSC22D3 0.43
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png transcriptional regulation TSC22D3 0.41
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding NFKB2 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization FOXO3 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.274
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding NfKb-p65/p50 0.365
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TSC22D3 0.41
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png relocalization FOXO1 0.308
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RELA 0.382
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization FOXO 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation TSC22D3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization FOXO4 0.256
Publications: 1 Organism: Homo Sapiens