Summary

Name MOB1A
Full Name MOB kinase activator 1A
Synonyms Mob1 alpha, Mob1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B | C2orf6, MOB4B, MOBK1B, MOBKL1B
Primary ID Q9H8S9
Links - -
Type protein
Relations 13
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ STK4up-regulates img/direct-activation.png phosphorylation MOB1A 0.896
Publications: 4 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3up-regulates img/direct-activation.png phosphorylation MOB1A 0.844
Publications: 5 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ MOB1Aup-regulates img/direct-activation.png binding LATS2 0.862
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ MOB1Aup-regulates img/direct-activation.png binding LATS1/2 0.94
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ MOB1Aup-regulates img/direct-activation.png binding LATS1 0.94
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates img/direct-activation.png phosphorylation MOB1A 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling