Cell cycle: G1/S phase transition

Pathway ID: SIGNOR-G1-S_transView in NDEx

Description: Cell cycle progression is a tightly regulated process that depends on the expression and activation of positive and negative regulators of the cell cycle machinery. The primary G1/S cell cycle checkpoint controls the commitment through the G1 phase to enter into the DNA synthesis S phase. Before the passage of the restriction point, activation of CCND- and CCNE-dependent CDKs initiates a sequence of events that eventually leads to the initiation of a full cell cycle. Under favorable growth conditions, CDK4/6 associate with CCNDs, phosphorylate and inactivate pRB, allowing the release of E2F and the transcription of its target genes. Under stress conditions (e,g DNA damage), the activity of CDKs can be blocked by natural inhibitors, CKI, belonging either to the INK4 or the CIP families, resulting in cell cycle arrest.

Curated by: Livia Perfetto

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

26 Seed Entities

Organism:
Name Primary ID
E2F1 Q01094
CDKN1B P46527
DNA damage SIGNOR-ST1
MYC P01106
ATR Q13535
G1/S transition SIGNOR-PH50
TGFBR1 P36897
CDKN1A P38936
TGFB1 P01137
Cell Cycle Block SIGNOR-PH10
GSK3B P49841
CDKN2B P42772
GFs SIGNOR-ST12
SMAD3 P84022
CDC25A P30304
CDKN2A Q8N726
CyclinD/CDK4 SIGNOR-C18
ATM Q13315
DNA replication SIGNOR-PH53
CyclinE/CDK2 SIGNOR-C16
RB1 P06400
TP53 P04637
CDKN2A P42771
CHEK2 O96017
MDM2 Q00987
AKT SIGNOR-PF24