Cell cycle: G2/M phase transition

Pathway ID: SIGNOR-G2-M_transView in NDEx

Description: Cell cycle progression is a tightly regulated process that depends on the expression and activation of positive and negative regulators of the cell cycle machinery. The term 'cell-cycle checkpoint' refers to mechanisms by which the cell actively halts progression through the cell cycle until it can ensure that an earlier process, such as DNA replication or mitosis, is complete. The G2 checkpoint (also known as the G2/M checkpoint) prevents cells from initiating mitosis when they experience DNA damage during G2, or when they progress into G2 with some unrepaired damage inflicted during previous phases (S or G1). The critical target of the G2 checkpoint is the mitosis-promoting activity of the cyclin B/CDK1 kinase, whose activation after various stresses is inhibited by ATM/ATR, CHK1/CHK2 and/or degradation and/or inhibition of the CDC25 family of phosphatases that normally activate CDK1 at the G2/M boundary (Kastan and Bartek, 2004).

Curated by: Livia Perfetto

36 Seed Entities

Organism:
Name Primary ID
MRE11/RAD50/NBS1 SIGNOR-C147
DNA_damage SIGNOR-ST1
CDKN2A Q8N726
PRKDC P78527
E2F1 Q01094
GFs SIGNOR-ST12
CyclinE/CDK2 SIGNOR-C16
Mitotic_checkpoint SIGNOR-PH28
ATR Q13535
CHEK2 O96017
CDKN1B P46527
Cell_cycle_block SIGNOR-PH10
DNA_repair SIGNOR-PH57
DNA_replication SIGNOR-PH53
RAD52 P43351
BRCA1 P38398
CyclinB/CDK1 SIGNOR-C17
CDC25A P30304
CDKN1A P38936
CyclinD/CDK4 SIGNOR-C18
ABL1 P00519
RAD51 Q06609
BUB1 O43683
AKT SIGNOR-PF24
CHEK1 O14757
MDM2 Q00987
RB1 P06400
MYC P01106
HIPK2 Q9H2X6
CDKN2A P42771
G2/M_transition SIGNOR-PH52
ATM Q13315
SMAD3 P84022
G1/S_transition SIGNOR-PH50
GSK3B P49841
TP53 P04637