| + |
Cell-Cell_contact | up-regulates 
|
STK4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230693 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22683405 |
In response to growth inhibitory signal (e.g. cellcell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
Cell-Cell_contact | up-regulates
|
STK3/4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269943 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22683405 |
In response to growth inhibitory signal (e.g. cell–cell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
Cell-Cell_contact | up-regulates
|
STK3 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22683405 |
In response to growth inhibitory signal (e.g. cellcell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
Cell-Cell_contact | up-regulates
|
TJP2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230703 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21529719 |
Another junction protein, the tight junction protein ZO-2, binds to YAP/TAZ, facilitating their nuclear translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
Cell-Cell_contact | up-regulates
|
AMOT/MPP5/INADL/LIN7C |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21529719 |
In vertebrates, cell density information feeds into the Hpo pathway, which is transmitted, in part, through the Crumbs polarity complex. The Crumbs complex contains Angiomotin (AMOT), a protein that binds YAP/TAZ and SMAD to inhibit their nuclear activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
Cell-Cell_contact | up-regulates
|
CDH1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230707 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24532814 |
Adherens junctions and the cadheriBeta-catenin complex have been found to activate the Hippo signaling pathway and inhibit cell growth. Cadherin-mediated stimulation of the Hippo signaling pathway requires cadherin ligation and the formation of a homophilic bond consistent with a role in cell-cell contact and works owing to phosphorylation of YAP by Lats and nuclear exclusion of YAP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
3.0
Cell-Cell_contact