Relation Results

Summary

Name Cell-Cell_contact
Primary ID SIGNOR-ST13
Type stimulus
Description Cell-Cell contact
Relations 6
Pathways Hippo Signaling

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Type: Score: Layout: SPV 
0.70.70.70.70.70.7Cell-Cell_contactSTK4CDH1TJP2AMOT/MPP5/INADL/LIN7CSTK3/4STK3

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Relations
Regulator
Mechanism
target
score ℹ
+ Cell-Cell_contactup-regulates img/indirect-activation.png STK4 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-230693 Homo sapiens
pmid sentence
In response to growth inhibitory signal (e.g. cell–cell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ Cell-Cell_contactup-regulates img/indirect-activation.png CDH1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-230707 Homo sapiens
pmid sentence
Adherens junctions and the cadheriBeta-catenin complex have been found to activate the Hippo signaling pathway and inhibit cell growth. Cadherin-mediated stimulation of the Hippo signaling pathway requires cadherin ligation and the formation of a homophilic bond – consistent with a role in cell-cell contact – and works owing to phosphorylation of YAP by Lats and nuclear exclusion of YAP.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ Cell-Cell_contactup-regulates img/indirect-activation.png TJP2 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-230703 Homo sapiens
pmid sentence
Another junction protein, the tight junction protein ZO-2, binds to YAP/TAZ, facilitating their nuclear translocation.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ Cell-Cell_contactup-regulates img/indirect-activation.png AMOT/MPP5/INADL/LIN7C 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-230700 Homo sapiens
pmid sentence
In vertebrates, cell density information feeds into the Hpo pathway, which is transmitted, in part, through the Crumbs polarity complex. The Crumbs complex contains Angiomotin (AMOT), a protein that binds YAP/TAZ and SMAD to inhibit their nuclear activity.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ Cell-Cell_contactup-regulates img/indirect-activation.png STK3/4 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269943 Homo sapiens
pmid sentence
In response to growth inhibitory signal (e.g. cell–cell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ Cell-Cell_contactup-regulates img/indirect-activation.png STK3 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-230696 Homo sapiens
pmid sentence
In response to growth inhibitory signal (e.g. cell–cell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
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