Summary

Name BRCA1
Full Name Breast cancer type 1 susceptibility protein
Synonyms RING finger protein 53 | RNF53
Primary ID P38398
Links - -
Type protein
Relations 76
Pathways DNA repair in cancer, Cell cycle: G2/M phase transition
Function E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage BRCA1 0.489
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage BRCA1 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BRCA1 0.791
Publications: 6 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.515
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.813
Publications: 11 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ down-regulates activity img/direct_inhibition.png dephosphorylation BRCA1 0.385
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.662
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation BRCA1 0.813
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ img/unknown.png phosphorylation BRCA1 0.351
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation BRCA1 0.379
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.661
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BRCA1 0.58
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ down-regulates img/direct_inhibition.png phosphorylation BRCA1 0.649
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.525
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.78
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BRCA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RNASEL 0.323
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png BRCA1 0.825
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination BRCA1 0.371
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding BRCA1 0.781
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination BRCA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BRCA1 0.906
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png DNA_repair 0.7
Publications: 1
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BRCA1 0.582
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BRCA1 0.845
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ down-regulates activity img/direct_inhibition.png binding ACACA 0.564
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding BRCA1 0.776
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT 0.525
Publications: 1 Organism: Mus Musculus
Pathways:Cell cycle: G2/M phase transition
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTSD 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BRCA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png ESR1 0.745
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATM 0.813
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TFF1 0.307
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BRCA1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BRCA1 0.582
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization BRCA1 0.836
Publications: 1
+ up-regulates activity img/direct-activation.png binding BRCA1 0.786
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MRE11/RAD50/NBS1 0.765
Publications: 1
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT1 0.525
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png Cell_cycle_progress 0.7
Publications: 1
+ up-regulates img/indirect-activation.png Cell_cycle_block 0.7
Publications: 1
Pathways:Cell cycle: G2/M phase transition
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1B 0.356
Publications: 1 Organism: Homo Sapiens
Pathways:Cell cycle: G2/M phase transition
+ up-regulates img/direct-activation.png ubiquitination RBBP8 0.836
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXC2 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ERCC6 0.455
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination FANCD2 0.839
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.791
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer, Cell cycle: G2/M phase transition
+ down-regulates quantity by destabilization img/direct_inhibition.png binding BRCA1 0.378
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BRCA1 0.277
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HSPA5 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding BRCA1-BARD1 complex 0.781
Publications: 1