Relation Results

Summary

Name BECN1
Full Name Beclin-1
Synonyms Coiled-coil myosin-like BCL2-interacting protein, Protein GT197 | GT197
Primary ID Q14457
Links - -
Type protein
Relations 38
Pathways Autophagy
Function Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidyl ...
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Type: Score: Layout: SPV 
0.20.4340.2990.3130.4170.7260.5250.2990.5280.2780.250.7380.7860.4120.3310.9370.9150.9360.8610.5260.4370.9060.20.70.5060.5460.770.4630.5280.3170.506STYK1BECN1MAPKAPK2CHEK2STK4ROCK1DAPK1EGFRJAK2USP13KLHL20ADNPBCL2AMBRA1TFEBCullin 3-RBX1-Skp1Vps34 Complex IBCL2L1PIK3C3UVRAGGOPCZWINTVps34 Complex IIACSS2Autophagosome_formationUSP10SH3GLB1ULK1NEDD4SIRT5

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ STYK1up-regulates activity img/direct-activation.png phosphorylation BECN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264568 Ser90 IPPARMMsTESANSF Homo sapiens HEK-293 Cell
pmid sentence
We also demonstrated that STYK1 elevated the serine phosphorylation of BECN1, thereby decreasing the interaction between BECN1 and BCL2. |The results indicated that the level of BECN1 S90 phosphorylation significantly increased after STYK1 overexpression, but not STYK1K147R mutant.|STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I
Publications: 1 Organism: Homo Sapiens
+ MAPKAPK2up-regulates activity img/direct-activation.png phosphorylation BECN1 0.434
Identifier Residue Sequence Organism Cell Line
SIGNOR-278342 Ser90 IPPARMMsTESANSF Homo sapiens
pmid sentence
Beclin 1 S90 is phosphorylated by MAPKAPK2 (MK2) and MAPKAPK3 (MK3).
Publications: 1 Organism: Homo Sapiens
+ CHEK2up-regulates activity img/direct-activation.png phosphorylation BECN1 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-264557 Ser90 IPPARMMsTESANSF Homo sapiens NCI-H1299 Cell
pmid sentence
We report that CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, thereby impairing Beclin 1-Bcl-2 autophagy-regulatory complex formation in a ROS-dependent fashion.|CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, promoting autophagy via Beclin 1 release from Bcl‐2 sequestration
Identifier Residue Sequence Organism Cell Line
SIGNOR-264556 Ser93 ARMMSTEsANSFTLI Homo sapiens NCI-H1299 Cell
pmid sentence
We report that CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, thereby impairing Beclin 1-Bcl-2 autophagy-regulatory complex formation in a ROS-dependent fashion.|CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, promoting autophagy via Beclin 1 release from Bcl‐2 sequestration
Publications: 2 Organism: Homo Sapiens
+ STK4up-regulates activity img/direct-activation.png phosphorylation BECN1 0.313
Identifier Residue Sequence Organism Cell Line
SIGNOR-278502 Thr108 GEASDGGtMENLSRR Homo sapiens
pmid sentence
These results suggest that Mst1 directly stimulates interaction between Beclin1 and Bcl-2.|We here demonstrate that Mst1-induced phosphorylation of Beclin1 in its BH3 domain at Thr 108 promotes binding of Beclin1 with Bcl-2/Bcl-xL.
Publications: 1 Organism: Homo Sapiens
+ ROCK1up-regulates activity img/direct-activation.png phosphorylation BECN1 0.417
Identifier Residue Sequence Organism Cell Line
SIGNOR-278198 Thr119 LSRRLKVtGDLFDIM Homo sapiens
pmid sentence
Beclin1 is phosphorylated by ROCK1 at T119.
Publications: 1 Organism: Homo Sapiens
+ DAPK1up-regulates img/direct-activation.png phosphorylation BECN1 0.726
Identifier Residue Sequence Organism Cell Line
SIGNOR-185589 Thr119 LSRRLKVtGDLFDIM Homo sapiens
pmid sentence
We found that DAPk phosphorylates Beclin 1 on T119, a critical residue within its BH3 domain, and thus promotes Beclin 1 dissociation from Bcl-X(L) and autophagy induction. Here we report that T119 phosphorylation also reduces the interaction between Beclin 1 and Bcl-2, in line with the high degree of structural homology between the BH3 binding pockets of Bcl-2 and Bcl-X(L) proteins.
Identifier Residue Sequence Organism Cell Line
SIGNOR-183548 Thr119 LSRRLKVtGDLFDIM Homo sapiens HEK-293 Cell
pmid sentence
The activated form of DAPK triggers autophagy in a beclin-1-dependent manner. DAPK phosphorylates beclin 1 on Thr 119 located at a crucial position within its BH3 domain, and thus promotes the dissociation of beclin 1 from Bcl-XL and the induction of autophagy.
Publications: 2 Organism: Homo Sapiens
+ EGFRdown-regulates activity img/direct_inhibition.png phosphorylation BECN1 0.525
Identifier Residue Sequence Organism Cell Line
SIGNOR-278357 Tyr233 EAQYQREySEFKRQQ Homo sapiens
pmid sentence
The mechanism by which EGFR suppresses Beclin 1 function involves EGFR interaction with two domains (BH3 and ECD) of Beclin 1; EGFR mediated multisite tyrosine phosphorylation of Beclin 1 on residues Y229, Y233 and Y352; and EGFR mediated alterations in the Beclin 1 interactome (increased binding to the negative regulators, Bcl-2 and Rubicon, and decreased binding to the VPS34 lipid kinase).|Thus, EGFR signaling suppresses autophagy via its interaction with Beclin 1 during normal mitogenic signaling as well as during aberrant cell proliferation in cancer cells.
Publications: 1 Organism: Homo Sapiens
+ JAK2up-regulates quantity img/direct-activation.png phosphorylation BECN1 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-278312 Tyr333 QRYRLVPyGNHSYLE Homo sapiens
pmid sentence
Importantly, JAK2 knockdown significantly abolished the increased levels of p-BECN1 (Y333) induced by IL-6 stimulation in both SW48 and LoVo cells (Fig. 3k and Supplementary Fig. 4f).|Taken together, these data indicate that JAK2 specifically phosphorylates BECN1 at Y333.
Publications: 1 Organism: Homo Sapiens
+ JAK2up-regulates activity img/direct-activation.png phosphorylation BECN1 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-277567 Tyr333 QRYRLVPyGNHSYLE Homo sapiens SW-48 Cell
pmid sentence
Mechanistically, IL-6 triggers the interaction between JAK2 and BECN1, where JAK2 phosphorylates BECN1 at Y333. We demonstrate that BECN1 Y333 phosphorylation is crucial for BECN1 activation and IL-6-induced autophagy by regulating PI3KC3 complex formation.
Publications: 1 Organism: Homo Sapiens
+ BECN1up-regulates quantity by stabilization img/direct-activation.png deubiquitination USP13 0.528
Identifier Residue Sequence Organism Cell Line
SIGNOR-260296 Homo sapiens H4 Neuroglioma Cell
pmid sentence
We found that endogenous Beclin1 can interact with USP13 and the interaction was reduced in the presence of spautin-1 (Figure 5C). Interestingly, the DUB activities were significantly increased when USP13 and USP10 coincubated together or with Beclin1 or all 3 proteins together, suggesting the DUB activity can be significantly enhanced when USP13 interacts with its substrate Beclin1 or USP10.
Publications: 1 Organism: Homo Sapiens
+ KLHL20down-regulates quantity by destabilization img/direct_inhibition.png binding BECN1 0.278
Identifier Residue Sequence Organism Cell Line
SIGNOR-272415 Homo sapiens HEK-293 Cell
pmid sentence
Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. KLHL20 promotes ubiquitination of phagophore-residing VPS34 and Beclin-1
Publications: 1 Organism: Homo Sapiens
+ ADNPup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BECN1 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-266760 Rattus norvegicus
pmid sentence
Here, we show for the first time that hippocampal ADNP deficiency paralleled reduced beclin1 expression which, in turn, parallels increased tauopathy and cell death. We now show that ADNP directly interacts with LC3B, implicating the requirement of a healthy ADNP system for the apoptotic/autophagy processes.
Publications: 1 Organism: Rattus Norvegicus
+ BCL2down-regulates img/direct_inhibition.png binding BECN1 0.738
Identifier Residue Sequence Organism Cell Line
SIGNOR-156941 Homo sapiens
pmid sentence
In mammalian cells, the antiapoptotic protein, bcl-2, binds to beclin 1 during nonstarvation conditions and inhibits its autophagy function.
Identifier Residue Sequence Organism Cell Line
SIGNOR-179084 Homo sapiens
pmid sentence
In mammalian cells, the antiapoptotic protein, bcl-2, binds to beclin 1 during nonstarvation conditions and inhibits its autophagy function.
Identifier Residue Sequence Organism Cell Line
SIGNOR-154477 Homo sapiens
pmid sentence
In mammalian cells, the antiapoptotic protein, bcl-2, binds to beclin 1 during nonstarvation conditions and inhibits its autophagy function.
Publications: 3 Organism: Homo Sapiens
Pathways:Autophagy
+ AMBRA1up-regulates activity img/direct-activation.png binding BECN1 0.786
Identifier Residue Sequence Organism Cell Line
SIGNOR-156409 Homo sapiens
pmid sentence
Here we show that Ambra1 (activating molecule in Beclin1-regulated autophagy), a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. We found that Ambra1 is a positive regulator of the Becn1-dependent programme of autophagy
Identifier Residue Sequence Organism Cell Line
SIGNOR-168252 Homo sapiens
pmid sentence
we show that the BECLIN 1-VPS34 complex is tethered to the cytoskeleton through an interaction between the BECLIN 1-interacting protein AMBRA1 and dynein light chains 1/2.
Publications: 2 Organism: Homo Sapiens
Tissue: Fibrosarcoma Cell
Pathways:Autophagy
+ TFEBup-regulates quantity by expression img/direct-activation.png transcriptional regulation BECN1 0.412
Identifier Residue Sequence Organism Cell Line
SIGNOR-276558
pmid sentence
As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes;
Publications: 1
+ Cullin 3-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination BECN1 0.331
Identifier Residue Sequence Organism Cell Line
SIGNOR-272419 Homo sapiens HEK-293 Cell
pmid sentence
Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. KLHL20 promotes ubiquitination of phagophore-residing VPS34 and Beclin-1
Publications: 1 Organism: Homo Sapiens
+ BECN1form complex img/form-complex.png binding Vps34 Complex I 0.937
Identifier Residue Sequence Organism Cell Line
SIGNOR-260315 in vitro
pmid sentence
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively.
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ BCL2L1down-regulates img/direct_inhibition.png binding BECN1 0.915
Identifier Residue Sequence Organism Cell Line
SIGNOR-154480 Homo sapiens
pmid sentence
The anti-apoptotic proteins bcl-2 and bcl-x(l) bind and inhibit beclin-1, an essential mediator of autophagy.
Publications: 1 Organism: Homo Sapiens
+ PIK3C3up-regulates activity img/direct-activation.png binding BECN1 0.936
Identifier Residue Sequence Organism Cell Line
SIGNOR-184521 Mus musculus
pmid sentence
The beclin 1-vps34 interaction regulates autophagy.
Publications: 1 Organism: Mus Musculus
Pathways:Autophagy
+ UVRAGup-regulates activity img/direct-activation.png binding BECN1 0.861
Identifier Residue Sequence Organism Cell Line
SIGNOR-150825 Homo sapiens HeLa Cell
pmid sentence
UVRAG interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenesis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-171902 Homo sapiens
pmid sentence
Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to regulate the lipid kinase Vps-34 protein and promote formation of Beclin 1-Vps34-Vps15 core complexes
Publications: 2 Organism: Homo Sapiens
Pathways:Autophagy
+ GOPCup-regulates img/direct-activation.png binding BECN1 0.526
Identifier Residue Sequence Organism Cell Line
SIGNOR-171896 Homo sapiens
pmid sentence
Npist binds beclin 1 by a ccd
Publications: 1 Organism: Homo Sapiens
+ BECN1up-regulates activity img/direct-activation.png binding ZWINT 0.437
Identifier Residue Sequence Organism Cell Line
SIGNOR-265027 Homo sapiens HeLa Cell
pmid sentence
We show that Beclin-1 interacts directly with Zwint-1-a component of the KMN (KNL-1/Mis12/Ndc80) complex-which is essential for kinetochore-microtubule interactions. This suggests that Beclin-1 acts downstream of the KMN complex to influence the recruitment of outer kinetochore proteins and promotes accurate kinetochore anchoring to the spindle during mitosis.
Publications: 1 Organism: Homo Sapiens
+ BECN1form complex img/form-complex.png binding Vps34 Complex II 0.906
Identifier Residue Sequence Organism Cell Line
SIGNOR-260319 in vitro
pmid sentence
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively.
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation BECN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276561
pmid sentence
As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes;
Publications: 1
+ BECN1up-regulates img/indirect-activation.png Autophagosome_formation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-219545 Homo sapiens
pmid sentence
Autophagy initiation signaling requires both the ULK1 kinase and the BECLIN 1–VPS34 core complex to generate autophagosomes, double-membraned vesicles that transfer cellular contents to lysosomes.
Publications: 1 Organism: Homo Sapiens
Tissue: Fibroma Cell
Pathways:Autophagy
+ USP10up-regulates quantity by stabilization img/direct-activation.png deubiquitination BECN1 0.506
Identifier Residue Sequence Organism Cell Line
SIGNOR-260299 Homo sapiens HEK-293T Cell
pmid sentence
Similarly, the overexpression of USP13 reduced the levels of ubiquitinated Beclin1 which was inhibited by spautin-1 (Figure 4E)
Publications: 1 Organism: Homo Sapiens
+ SH3GLB1up-regulates img/direct-activation.png binding BECN1 0.546
Identifier Residue Sequence Organism Cell Line
SIGNOR-171899 Homo sapiens
pmid sentence
Bif-1 forms a complex with beclin1 through uvrag and promotes the activation of the class iii pi3 kinase, vps34, in mammalian cells.
Publications: 1 Organism: Homo Sapiens
+ ULK1up-regulates activity img/direct-activation.png phosphorylation BECN1 0.77
Identifier Residue Sequence Organism Cell Line
SIGNOR-278503 Homo sapiens
pmid sentence
In the nucleation step of autophagy, The ULK1 complex phosphorylates and activates the Beclin-1-VPS34 complex.
Publications: 1 Organism: Homo Sapiens
+ NEDD4up-regulates quantity by stabilization img/direct-activation.png ubiquitination BECN1 0.463
Identifier Residue Sequence Organism Cell Line
SIGNOR-278558 Homo sapiens
pmid sentence
BECN1 stability was increased by NEDD4 via K6 and K27 ubiquitination during autophagy induction, thereby promoting autophagy activation.|Further, NEDD4 mediated K6- and K27- linkage ubiquitination of BECN1, leading to elevated stability of BECN1 and increased autophagy.
Publications: 1 Organism: Homo Sapiens
+ USP13up-regulates quantity by stabilization img/direct-activation.png deubiquitination BECN1 0.528
Identifier Residue Sequence Organism Cell Line
SIGNOR-260295 Homo sapiens HEK-293T Cell
pmid sentence
Similarly, the overexpression of USP13 reduced the levels of ubiquitinated Beclin1 which was inhibited by spautin-1 (Figure 4E)
Publications: 1 Organism: Homo Sapiens
+ SIRT5up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BECN1 0.317
Identifier Residue Sequence Organism Cell Line
SIGNOR-261206 Homo sapiens
pmid sentence
In SIRT5 silenced Mero-14 cells, beclin-1 protein levels were downregulated upon rotenone and resveratrol treatment. In summary, in most cases, where significant effects were detected, SIRT1, SIRT3, and SIRT5 had positive effects on beclin1 and LC3II/LC3I ratio
Publications: 1 Organism: Homo Sapiens
+ BECN1up-regulates quantity by stabilization img/direct-activation.png deubiquitination USP10 0.506
Identifier Residue Sequence Organism Cell Line
SIGNOR-260298 Homo sapiens H4 Neuroglioma Cell
pmid sentence
Interestingly, Beclin1 also controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities.
Publications: 1 Organism: Homo Sapiens
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