Summary

Name BECN1
Full Name Beclin-1
Synonyms Coiled-coil myosin-like BCL2-interacting protein, Protein GT197 | GT197
Primary ID Q14457
Links - -
Type protein
Relations 28
Pathways Autophagy
Function Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation BECN1 0.305
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BECN1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BECN1 0.721
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination USP10 0.485
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BECN1 0.325
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination BECN1 0.485
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BECN1 0.934
Publications: 1 Organism: Mus Musculus
Pathways:Autophagy
+ down-regulates img/direct_inhibition.png binding BECN1 0.728
Publications: 3 Organism: Homo Sapiens
Pathways:Autophagy
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BECN1 0.254
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding BECN1 0.566
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Vps34 Complex I 0.935
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ up-regulates activity img/direct-activation.png binding BECN1 0.78
Publications: 2 Organism: Homo Sapiens
Tissue: Fibrosarcoma Cell
Pathways:Autophagy
+ down-regulates quantity by destabilization img/direct_inhibition.png binding BECN1 0.283
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination BECN1 0.509
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BECN1 0.857
Publications: 2 Organism: Homo Sapiens
Pathways:Autophagy
+ down-regulates img/direct_inhibition.png binding BECN1 0.916
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Autophagosome_formation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Fibroma Cell
Pathways:Autophagy
+ up-regulates activity img/direct-activation.png binding ZWINT 0.449
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BECN1 0.543
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Vps34 Complex II 0.904
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination USP13 0.509
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination BECN1 0.338
Publications: 1 Organism: Homo Sapiens