4.0
Summary
| Name |  PLCB1View Modifications |
| Full Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
| Synonyms | PLC-154, Phosphoinositide phospholipase C-beta-1, Phospholipase C-I, PLC-I, Phospholipase C-beta-1, PLC-beta-1 | KIAA0581 |
| Primary ID | Q9NQ66 |
| Links |  -  -  |
| Type | protein |
| Relations | 17 |
| Pathways | GPCR_Breast Cancer, Dopaminergic Synapse, GPCR_CRC, GPCR_HCC, GPCR_Pancreatic, GPCR_Prostate CancerCancer, Glutamatergic synapse, Oxytocin signaling, Thyroid Hormone Metabolism |
| Function | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA |
phosphorylation
|
PLCB1 | 0.727 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Thyroid Hormone Metabolism | |||
| + | MAPK1 | up-regulates activity 
phosphorylation
|
PLCB1 | 0.389 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAPK3 | up-regulates activity
phosphorylation
|
PLCB1 | 0.403 |
| Publications: | 1 | Organism: | In Vitro | |
| + | GNB1 | down-regulates 
binding
|
PLCB1 | 0.505 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GNAQ | up-regulates
binding
|
PLCB1 | 0.779 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Dopaminergic Synapse, Oxytocin signaling, Thyroid Hormone Metabolism | |||
| + | GNA11 | up-regulates activity
binding
|
PLCB1 | 0.637 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Thyroid Hormone Metabolism | |||
| + | PLCB1 | up-regulates quantity
chemical modification
|
1D-myo-inositol 1,4,5-trisphosphate | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Dopaminergic Synapse, Glutamatergic synapse, Oxytocin signaling, Thyroid Hormone Metabolism | |||
| + | PLCB1 | up-regulates
binding
|
GNA11 | 0.637 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Thyroid Hormone Metabolism | |||
| + | DVL1 | up-regulates activity
|
PLCB1 | 0.272 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DVL2 | up-regulates activity
|
PLCB1 | 0.266 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | up-regulates activity
phosphorylation
|
PLCB1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Oxytocin signaling | |||
| + | Gbeta | up-regulates activity
phosphorylation
|
PLCB1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | GNA14 | up-regulates activity
binding
|
PLCB1 | 0.489 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | PLCB1 | up-regulates quantity
chemical modification
|
1,2-diacyl-sn-glycerol | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Oxytocin signaling, Thyroid Hormone Metabolism | |||
| + | DVL3 | up-regulates activity
|
PLCB1 | 0.343 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GNAS | up-regulates activity
binding
|
PLCB1 | 0.32 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glutamatergic synapse, Thyroid Hormone Metabolism | |||
| + | GNA15 | up-regulates activity
binding
|
PLCB1 | 0.504 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |