Summary

Name TBK1
Full Name Serine/threonine-protein kinase TBK1
Synonyms NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1 | NAK
Primary ID Q9UHD2
Links - -
Type protein
Relations 69
Pathways COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
Inhibitors N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Function Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359, PubMed:32404352). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TNIP1 0.383
Publications: 2
+ up-regulates activity img/direct-activation.png phosphorylation HTT 0.294
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png phosphorylation SIKE1 0.707
Publications: 6 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PBXIP1 0.294
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRF5 0.557
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TBK1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STX17 0.296
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DDAH2 0.2
Publications: 4
+ up-regulates activity img/direct-activation.png phosphorylation STING1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.468
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation IRF3 0.816
Publications: 9 Organism: In Vitro, Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation SQSTM1 0.701
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT6 0.66
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.417
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT 0.417
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TBK1 0.422
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.602
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TBK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRPS1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PRPS2 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation TBK1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TBK1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TBK1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TBK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA
+ down-regulates img/direct_inhibition.png ubiquitination TBK1 0.567
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NfKb-p65/p50 0.577
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
+ down-regulates activity img/direct_inhibition.png chemical activation TBK1 0.8
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition TBK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TBK1 0.91
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
+ down-regulates activity img/direct_inhibition.png dephosphorylation TBK1 0.36
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding TBK1 0.785
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TBK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
+ up-regulates activity img/direct-activation.png binding TBK1 0.629
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
+ up-regulates activity img/direct-activation.png binding TBK1 0.534
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TBK1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ up-regulates activity img/direct-activation.png binding TBK1 0.814
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
+ down-regulates activity img/direct_inhibition.png binding TBK1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png relocalization TBK1 0.623
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation REL/RELA 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TBK1 0.9
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates activity img/direct_inhibition.png binding TBK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ up-regulates img/direct-activation.png phosphorylation REL 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TBK1 0.293
Publications: 1
+ up-regulates activity img/direct-activation.png binding IKBKE 0.629
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors
+ up-regulates img/direct-activation.png binding IKBKB 0.412
Publications: 1 Organism: Homo Sapiens