| + |
alpha-D-glucose 6-phosphate(2-) | up-regulates quantity 
precursor of
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis, Glycolysis and Gluconeogenesis |
| + |
Gluconeogenesis | up-regulates
|
α-D-glucose |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis |
| + |
SLC2A4 | up-regulates quantity
relocalization
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267291 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17403369 |
Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
glycogen | up-regulates quantity
precursor of
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267397 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3346228 |
Mammalian glycogen phosphorylases are found in at least three isozymic forms that can be distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed […] Each phosphorylase isozyme fulfills different physiological requirements even though all forms of the enzyme catalyze the same reaction, the phosphorolysis of glycogen to yield glucose 1-phosphate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis |
| + |
HK1 | down-regulates quantity 
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
Hexokinase | down-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycolysis and Gluconeogenesis |
| + |
G6PC2 | up-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266565 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC2A2 | up-regulates quantity
relocalization
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267385 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25421524 |
The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
G6PC3 | up-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266566 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCK | down-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266458 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
HK3 | down-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
G6P | up-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266567 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
α-D-glucose | up-regulates quantity
precursor of
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenesis, Glycogenolysis, Glycolysis and Gluconeogenesis |
| + |
HK2 | down-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266456 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
G6PC1 | up-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12093795 |
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-D-glucose | up-regulates
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23680095 |
Glycolysis is a cytoplasmic non-oxidative reaction for glucose degradation that is composed of 9 pro cesses. A non-specific HK enzyme by using ATP phosphorylates glucose following entrance to the cell and converts it to G6P. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycogenolysis |
| + |
SLC2A1 | up-regulates quantity
relocalization
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267458 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23506862 |
GLUT1 plays a critical role in cerebral glucose uptake as the major GLUT isoform expressed in brain endothelial cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PYGB | up-regulates quantity
chemical modification
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3346228 |
Mammalian glycogen phosphorylases are found in at least three isozymic forms that can be distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed […] Each phosphorylase isozyme fulfills different physiological requirements even though all forms of the enzyme catalyze the same reaction, the phosphorolysis of glycogen to yield glucose 1-phosphate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC2A3 | up-regulates quantity
relocalization
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23506862 |
The SLC2A3 gene encoding GLUT3 was first cloned from a human fetal skeletal muscle cell line (Kayano et al., 1988). It shares ~64% sequence identity with SLC2A1. GLUT3 has a higher apparent affinity (lower Km) and a higher maximum turnover number for glucose than the other Class 1 GLUT proteins, and its principal physiological substrate is clearly D-glucose |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
3.0
α-D-glucose