| + |
SLC9A6 | up-regulates quantity 
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265605 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A1 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264400 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN4A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A1 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265600 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A4 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265603 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN1A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253402 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A2 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264399 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN8A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253406 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCNN1A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269275 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26772908 |
The epithelial sodium channel (ENaC) is composed of three homologous subunits and allows the flow of Na(+) ions across high resistance epithelia, maintaining body salt and water homeostasis. ENaC dependent reabsorption of Na(+) in the kidney tubules regulates extracellular fluid (ECF) volume and blood pressure by modulating osmolarity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A7 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265606 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A4 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264402 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A3 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265602 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN10A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253408 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC5A5 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266961 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 28192058 |
Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na+/I- symporter (NIS). In the thyroid, NIS-mediated I- uptake plays a pivotal role in thyroid hormone (TH) biosynthesis. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Thyroid Hormone Metabolism |
| + |
SCN9A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253403 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCNN1B | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26772908 |
The epithelial sodium channel (ENaC) is composed of three homologous subunits and allows the flow of Na(+) ions across high resistance epithelia, maintaining body salt and water homeostasis. ENaC dependent reabsorption of Na(+) in the kidney tubules regulates extracellular fluid (ECF) volume and blood pressure by modulating osmolarity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A3 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264401 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A2 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265601 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN11A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253407 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATP1A3 | down-regulates quantity 
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265792 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22797008 |
The sodium/potassium transporting ATPase subunit alpha-3 (AT1A3; syn.: sodium pump subunit alpha-3; E.C. 3.6.3.9; UniProtKB ID: Q6PIC6) belongs to the cation transport ATPase (P-type) 3.A.3 family catalyzing hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action generates the electrochemical gradient of sodium and potassium ions thus providing energy for active transport of various nutrients. Three sodium/potassium transporting ATPase isoforms are expressed in the brain but AT1A3 is detectable in neurons exclusively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sodium(1+) | up-regulates 
|
Excitatory_synaptic_transmission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265182 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 29863287 |
Axonal excitability is an important determinant for the accuracy, direction, and velocity of neuronal signaling. The mechanisms underlying spike generation in the axonal initial segment and transmitter release from presynaptic terminals have been intensely studied and revealed a role for several specific ionic conductances, including the persistent sodium current (INaP ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NALCN | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265181 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 32698188 |
Persistently depolarizing sodium (Na+) leak currents enhance electrical excitability. The ion channel responsible for the major background Na+ conductance in neurons is the Na+ leak channel, non-selective (NALCN) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN5A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253401 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC24A5 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264403 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 30173760 |
K+-dependent Na+-Ca2+ Exchangers (NCKX) are bi-directional plasma membrane Ca2+ transporters which belong to the Solute Carrier Family 24 A (SLC24 A) of membrane transporters. NCKXs operate via the alternating access model and mediate the extrusion of one Ca2+ ion coupled with one K+ ion in exchange for four Na+ ions (4Na+↔ 1Ca2+ + 1 K+) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN2A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253404 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A9 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265608 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A8 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265607 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCNN1G | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26772908 |
The epithelial sodium channel (ENaC) is composed of three homologous subunits and allows the flow of Na(+) ions across high resistance epithelia, maintaining body salt and water homeostasis. ENaC dependent reabsorption of Na(+) in the kidney tubules regulates extracellular fluid (ECF) volume and blood pressure by modulating osmolarity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCN3A | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253409 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27262167 |
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC9A5 | up-regulates quantity
relocalization
|
sodium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265604 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 31507243 |
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the electroneutral exchange of Na+ and H+ across cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
sodium(1+)
