| + |
CAMK2G | down-regulates activity 
phosphorylation
|
Adenylate_cyclase |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267845 |
Ser1076 |
NVASRMEsTGVMGNI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 8798667 |
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. | Site-directed mutagenesis of a CaM kinase II consensus site (Ser-1076 to Ala-1076) in III-AC greatly reduced Ca2+-stimulated phosphorylation and inhibition of III-AC in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI2 | down-regulates
binding
|
Adenylate_cyclase |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAL | up-regulates activity 
binding
|
Adenylate_cyclase |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267852 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
D1-class dopamine receptors (D1 and D5) activate the G s/olf family of G proteins to stimulate cAMP produc tion by AC and are found exclusively postsynaptically on dopamine-receptive cells, such as GABA-ergic medium spiny neurons (MSNs) in the striatum. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI1 | down-regulates activity
binding
|
Adenylate_cyclase |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267853 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15922020 |
Activation of receptors coupled to inhibitory G proteins (Galpha i/o) has opposing consequences for cyclic AMP accumulation and the activity of cyclic AMP-dependent protein kinase, depending on the duration of stimulation. Acute activation inhibits the activity of adenylate cyclase, thereby attenuating cyclic AMP accumulation; in contrast, persistent activation of Galpha i/o-coupled receptors produces a paradoxical enhancement of adenylate cyclase activity, thus increasing cyclic AMP accumulation when the action of the inhibitory receptor is terminated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
GNAI3 | down-regulates activity
binding
|
Adenylate_cyclase |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267851 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19703466 |
Adenylate cyclase is regulated by stimulatory hormones through Gs(alpha s beta gamma) and inhibitory hormones through Gi(alpha i beta gamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Adenylate_cyclase | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267844 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis, Oxytocin signaling |
| + |
NF1 | up-regulates 
|
Adenylate_cyclase |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267847 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24431436 |
Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267846 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24431436 |
Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GNAS | up-regulates activity
binding
|
Adenylate_cyclase |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267848 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17652154 |
Because adenylyl cyclases are directly activated by G(s)alpha and the carboxyl termini of the various Galpha proteins determine their receptor coupling specificity, we proposed a set of chimeric G(s)alpha where the COOH-terminal five amino acids are replaced by those of other Galpha proteins and used these to dissect the potential Galpha linked to a given GPCR |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB5 | down-regulates activity
binding
|
Adenylate_cyclase |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267850 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
The D2-class dopamine receptors (D2, D3, and D4) couple to the Gi/o family of G proteins and thus induce inhibition of AC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
Adenylate_cyclase | down-regulates quantity
chemical modification
|
ATP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11376933 |
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
GNAS | up-regulates activity
binding
|
Adenylate_cyclase |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268693 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12145344 |
HETEROTRIMERIC G PROTEINS are essential for cell signaling throughout the body. The stimulatory G protein, Gs, couples activation of a host of different transmembrane receptors to adenylyl cyclase stimulation, leading to intracellular generation of cAMP |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
3.0
Adenylate_cyclase