| + |
GNAI1 | down-regulates activity 
binding
|
ADCY1 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15922020 |
Activation of receptors coupled to inhibitory G proteins (Galpha i/o) has opposing consequences for cyclic AMP accumulation and the activity of cyclic AMP-dependent protein kinase, depending on the duration of stimulation. Acute activation inhibits the activity of adenylate cyclase, thereby attenuating cyclic AMP accumulation; in contrast, persistent activation of Galpha i/o-coupled receptors produces a paradoxical enhancement of adenylate cyclase activity, thus increasing cyclic AMP accumulation when the action of the inhibitory receptor is terminated. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19703466 |
GTP-bound, active WT Gαi1 acts to inhibit AC, resulting in a decreased concentration of intracellular cAMP. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
ADCY1 | up-regulates 
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22863277 |
To further explore the role of camp signaling in the hippo pathway, we treated cells with forskolin, an activator of adenylyl cyclase that results in cAMP production. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Typically Gas stimulates adenylyl cyclase and increases levels of cyclic amp (camp), whereas galfai inhibits adenylyl cyclase and lowers camp levels, and members of the galfaq family bind to and activate phospholipase c (plc), which cleaves phosphatidylinositol bisphosphate (pip2) into diacylglycerol and inositol triphosphate (ip3). The gbeta subunits and ggamma subunits function as a dimer to activate many molecules, including phospholipases, ion channels and lipid kinases. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamatergic synapse, GABAergic synapse , Sonic Hedgehog, Neurotransmitters release, Thyroid Hormone Metabolism, WNT Signaling, WNT Signaling and Myogenesis |
| + |
GNAI2 | down-regulates activity
binding
|
ADCY1 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19703466 |
Adenylate cyclase is regulated by stimulatory hormones through Gs(alpha s beta gamma) and inhibitory hormones through Gi(alpha i beta gamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GNAI3 | down-regulates
binding
|
ADCY1 |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-38032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-38029 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ADCY1 | up-regulates activity 
|
PRKACA |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262528 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27065076 |
Adenylate cyclases (AC) produce cAMP from adenosin-tri-phosphate (ATP). High levels of cytosolic cAMP lead to activation of protein kinase A (PKA) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
GNB5 | down-regulates activity
binding
|
ADCY1 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264996 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
The D2-class dopamine receptors (D2, D3, and D4) couple to the Gi/o family of G proteins and thus induce inhibition of AC |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | GABAergic synapse |
| + |
GNAI3 | down-regulates activity
binding
|
ADCY1 |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19703466 |
Adenylate cyclase is regulated by stimulatory hormones through Gs(alpha s beta gamma) and inhibitory hormones through Gi(alpha i beta gamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAL | up-regulates activity
binding
|
ADCY1 |
0.519 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264992 |
|
|
Homo sapiens |
Dopaminergic Neuron |
| pmid |
sentence |
| 21303898 |
D1-class dopamine receptors (D1 and D5) activate the G s/olf family of G proteins to stimulate cAMP produc tion by AC and are found exclusively postsynaptically on dopamine-receptive cells, such as GABA-ergic medium spiny neurons (MSNs) in the striatum. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI2 | down-regulates
binding
|
ADCY1 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37973 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GNAS | up-regulates activity
binding
|
ADCY1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17652154 |
Because adenylyl cyclases are directly activated by G(s)alpha and the carboxyl termini of the various Galpha proteins determine their receptor coupling specificity, we proposed a set of chimeric G(s)alpha where the COOH-terminal five amino acids are replaced by those of other Galpha proteins and used these to dissect the potential Galpha linked to a given GPCR |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamatergic synapse, Thyroid Hormone Metabolism, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
ADCY1 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glutamatergic synapse, GABAergic synapse , Sonic Hedgehog, Neurotransmitters release, Thyroid Hormone Metabolism, WNT Signaling, WNT Signaling and Myogenesis |
3.0
ADCY1
- 
- 