Summary

Name MMP2
Full Name 72 kDa type IV collagenase
Synonyms 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1 | CLG4A
Primary ID P08253
Links - -
Type protein
Relations 22
Function Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage A2M 0.615
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage MMP2 0.384
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage DCN 0.68
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage HAPLN1 0.346
Publications: 2 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage PZP 0.334
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/direct-activation.png binding LRP2 0.353
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding MMP2 0.615
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage LAMC2 0.446
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage Laminin-5 0.434
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ECM_disassembly 0.7
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding MMP2 0.334
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.464
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ECM 0.7
Publications: 1
+ up-regulates img/direct-activation.png cleavage TGFB1 0.576
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.389
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP2 0.341
Publications: 1 Organism: Homo Sapiens