Summary

Name TRIM27
Full Name Zinc finger protein RFP
Synonyms RING finger protein 76, Ret finger protein, Tripartite motif-containing protein 27 | RFP, RNF76
Primary ID P14373
Links - -
Type protein
Relations 10
Function E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination WASHC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRIM27 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.28
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png ubiquitination PIK3C2B 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK11 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/indirect-activation.png MAPK8 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/indirect-activation.png MAPK13 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/indirect-activation.png MAPK14 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/indirect-activation.png Cell death 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/indirect-activation.png MAPK12 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney