| + |
CSNK2A1 | down-regulates 
phosphorylation
|
ATF1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167544 |
Ser36 |
AQQVSSLsESEESQD |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
Although the functional impact of ck-mediated atf1 phosphorylation is still unclear, we found that mutation of ser-36 and ser-41 increased cbp kix domain binding by up to four fold (fig. 2g). This result is consistent with the negative impact of ck-mediated phosphorylation on cbp binding affinity of creb that we previously reported |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167548 |
Ser38 |
QVSSLSEsEESQDSS |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
These data suggested that atf1 is always hyperphosphorylated on the ck sites in vivo. Also, the antibody reactivity suggested that in addition to ser-36 and ser-41, ser-38 and ser-44 were phosphorylated in vivo. To accommodate these findings, we propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167552 |
Ser41 |
SLSESEEsQDSSDSI |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
Although the functional impact of ck-mediated atf1 phosphorylation is still unclear, we found that mutation of ser-36 and ser-41 increased cbp kix domain binding by up to four fold (fig. 2g). This result is consistent with the negative impact of ck-mediated phosphorylation on cbp binding affinity of creb that we previously reported |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167556 |
Ser44 |
ESEESQDsSDSIGSS |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
These data suggested that atf1 is always hyperphosphorylated on the ck sites in vivo. Also, the antibody reactivity suggested that in addition to ser-36 and ser-41, ser-38 and ser-44 were phosphorylated in vivo. To accommodate these findings, we propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PPP2R5C | up-regulates 
dephosphorylation
|
ATF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167560 |
Ser36 |
AQQVSSLsESEESQD |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167564 |
Ser38 |
QVSSLSEsEESQDSS |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167568 |
Ser41 |
SLSESEEsQDSSDSI |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167572 |
Ser44 |
ESEESQDsSDSIGSS |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf4 |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates activity
phosphorylation
|
ATF1 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278909 |
Ser51 |
SSDSIGSsQKAHGIL |
Homo sapiens |
|
| pmid |
sentence |
| 20730097 |
Exposure to DNA damage further induced ATF1 phosphorylation on Ser-51 by ATM in a manner that required prior phosphorylation of the upstream CK residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2G | up-regulates activity
phosphorylation
|
ATF1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250692 |
Ser63 |
GILARRPsYRKILKD |
|
|
| pmid |
sentence |
| 8663317 |
Phosphopeptide mapping analysis and Western blotting studies demonstrated that in vitro, CaMK II phosphorylates only Ser63 (corresponding to Ser133 of CREB), which is essential for the activation, and not Ser72 (corresponding to Ser142 of CREB), which is a negative regulation site. |
|
| Publications: |
1 |
| + |
RPS6KA4 | up-regulates activity
phosphorylation
|
ATF1 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249145 |
Ser63 |
GILARRPsYRKILKD |
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 11909979 |
Using embryonic fibroblasts derived from these mice we were able to demonstrate an important role for these enzymes in the activation of CREB and the closely related transcription factor ATF1. | Our results clearly demonstrate that MSK1 and MSK2 are the major, if not the only, protein kinases that mediate the phosphorylation of CREB at Ser133 and of ATF1 at Ser63 in fibroblasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CDK3 | up-regulates
phosphorylation
|
ATF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180920 |
Ser63 |
GILARRPsYRKILKD |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 18794154 |
Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformationwe found that cdk3 phosphorylates activating transcription factor 1 (atf1) at serine 63 and enhances the transactivation and transcriptional activities of atf1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
CSNK2A1 | up-regulates
phosphorylation
|
ATF1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42565 |
Ser63 |
GILARRPsYRKILKD |
Homo sapiens |
|
| pmid |
sentence |
| 8663317 |
Camk ii phosphorylates only ser63 (corresponding to ser133 of creb), which is essential for the activation, and not ser72 (corresponding to ser142 of creb), which is a negative regulation site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA5 | up-regulates activity
phosphorylation
|
ATF1 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95318 |
Ser63 |
GILARRPsYRKILKD |
Homo sapiens |
|
| pmid |
sentence |
| 12414794 |
We find that activation of the c-jun promoter through the atf1 site requires phosphorylation of atf1 at serine 63. atf1 can be phosphorylated by mitogen- and stress-activated protein kinase 1 (msk1), which is activated by egf and erk1/2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249144 |
Ser63 |
GILARRPsYRKILKD |
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 11909979 |
Using embryonic fibroblasts derived from these mice we were able to demonstrate an important role for these enzymes in the activation of CREB and the closely related transcription factor ATF1. | Our results clearly demonstrate that MSK1 and MSK2 are the major, if not the only, protein kinases that mediate the phosphorylation of CREB at Ser133 and of ATF1 at Ser63 in fibroblasts |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | P38 Signaling |
| + |
CAMK1 | up-regulates activity
phosphorylation
|
ATF1 |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250611 |
Ser63 |
GILARRPsYRKILKD |
in vitro |
|
| pmid |
sentence |
| 8663317 |
Phosphopeptide mapping analysis and Western blotting studies demonstrated that in vitro, CaMK II phosphorylates only Ser63 (corresponding to Ser133 of CREB), which is essential for the activation, and not Ser72 (corresponding to Ser142 of CREB), which is a negative regulation site. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRKACA | up-regulates activity
phosphorylation
|
ATF1 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250336 |
Ser63 |
GILARRPsYRKILKD |
in vitro |
|
| pmid |
sentence |
| 9016641 |
PKA catalytic subunit phosphorylates ATF-1 at Ser63 and that phosphorylation is essential for efficient DNA binding by ATF-1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ATF1 | up-regulates quantity by expression 
transcriptional regulation
|
PCSK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253742 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8999965 |
it was shown that both CREB-1 and ATF-1 transactivate the human PC1 promoter in transient transfection experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF1 | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271686 |
|
|
|
|
| pmid |
sentence |
| 10391889 |
Phosphorylated CREB and ATF1 then bind to the CRE of the egr-1 promoter and cause a stress-dependent transcriptional activation of this gene. |
|
| Publications: |
1 |
| + |
RPS6KA3 | up-regulates activity
phosphorylation
|
ATF1 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10723128 |
ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinase. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB.|ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF1 | down-regulates quantity by repression 
transcriptional regulation
|
FTH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253741 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17565989 |
Here we found that ATF1 (activating transcription factor 1) is a transcriptional repressor of the ferritin H ARE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates
phosphorylation
|
ATF1 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Msk1 and msk2 directly phosphorilate and activate transcription factors such as creb1, atf1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11909979 |
Msk1 and msk2 directly phosphorilate and activate transcription factors such as creb1, atf1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ATF1 | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254521 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10540320 |
Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF1B | up-regulates activity
binding
|
ATF1 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241320 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9671480 |
The mammalian two-hybrid system showed that the region aa 393 to 476 of LFB3 is involved in the interaction with CREB or ATF1. The importance of this region for mediating cAMP induction was confirmed in transient transfection assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
ATF1
- 
- 