Relation Results

Summary

Name TBXA2R
Full Name Thromboxane A2 receptor
Synonyms TXA2-R, Prostanoid TP receptor
Primary ID P21731
Links - -
Type protein
Relations 14
Function Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activat ...
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Type: Score: Layout: SPV 
0.5070.20.20.4780.6450.5610.80.2510.4560.2620.80.2PRKCATBXA2RGRK2GRK3PRKACAGNAQGNA139,11-Methanoepoxy PGH2GNAI1GNA14EGR1thromboxaneSP1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCAdown-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.507
Identifier Residue Sequence Organism Cell Line
SIGNOR-274092 Ser145 FSRPAVAsQRRAWAT Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Publications: 1 Organism: Homo Sapiens
+ GRK2down-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274088 Ser239 AQQRPRDsEVEMMAQ Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274089 Ser357 RLPGSSDsRASASRA Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Publications: 2 Organism: Homo Sapiens
+ GRK3down-regulates activity img/direct_inhibition.png phosphorylation TBXA2R (isoform 2) 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-274090 Ser239 AQQRPRDsEVEMMAQ Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274091 Ser357 RLPGSSDsRASASRA Homo sapiens
pmid sentence
 These data suggest a model whereby agonist-induced PKC phosphorylation of Ser(145) partially impairs TPbeta signalling while GRK2/3 phosphorylation at both Ser(239) and Ser(357) within its IC(3) and C-tail domains, respectively, sterically inhibits G-protein coupling, profoundly desensitizing signalling, and promotes beta-arrestin association and, in turn, facilitates TPbeta internalization.
Publications: 2 Organism: Homo Sapiens
+ PRKACA img/unknown.png phosphorylation TBXA2R 0.478
Identifier Residue Sequence Organism Cell Line
SIGNOR-90976 Ser331 STRPRSLsLQPQLTQ Homo sapiens
pmid sentence
Ser-331 was found to be involved in pka-mediated phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ TBXA2Rup-regulates activity img/direct-activation.png binding GNAQ 0.645
Identifier Residue Sequence Organism Cell Line
SIGNOR-256887 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ TBXA2Rup-regulates activity img/direct-activation.png binding GNA13 0.561
Identifier Residue Sequence Organism Cell Line
SIGNOR-257139 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ 9,11-Methanoepoxy PGH2up-regulates activity img/direct-activation.png chemical activation TBXA2R 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257589 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ TBXA2Rup-regulates activity img/direct-activation.png binding GNAI1 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-256744 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ TBXA2Rup-regulates activity img/direct-activation.png binding GNA14 0.456
Identifier Residue Sequence Organism Cell Line
SIGNOR-257023 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ EGR1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TBXA2R 0.262
Identifier Residue Sequence Organism Cell Line
SIGNOR-254253 Homo sapiens
pmid sentence
Collectively, data establish that regulated WT1 followed by sequential Egr1 and Sp1 binding to elements within Prm1 mediate repression and subsequent induction of TPα during differentiation into the megakaryocytic phenotype, shedding significant insights into factors regulating TPα expression therein.
Publications: 1 Organism: Homo Sapiens
+ thromboxaneup-regulates activity img/direct-activation.png chemical activation TBXA2R 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-254264
pmid sentence
Thromboxane plays an essential role in hemostasis, regulating platelet aggregation and vessel tone. In humans, it signals through the TPalpha and TPbeta isoforms that are transcriptionally regulated by distinct promoters Prm1 and Prm3, respectively.
Publications: 1
+ SP1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TBXA2R 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254254 Homo sapiens HEL Cell
pmid sentence
Collectively, data establish that regulated WT1 followed by sequential Egr1 and Sp1 binding to elements within Prm1 mediate repression and subsequent induction of TPα during differentiation into the megakaryocytic phenotype, shedding significant insights into factors regulating TPα expression therein.
Publications: 1 Organism: Homo Sapiens
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