Summary

Name N
Full Name Nucleoprotein
Synonyms Nucleocapsid protein, NC, Protein N |
Primary ID P59595
Links - -
Type protein
Relations 21
Pathways COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV CYTOKINE STORM, SARS-CoV FIBROSIS, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
Function Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage N 0.2
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png sumoylation N 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINE1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV FIBROSIS
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ATF2 0.2
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CREB1 0.2
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates activity img/direct-activation.png transcriptional regulation PTGS2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FOSB 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding SMAD3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV FIBROSIS
+ down-regulates activity img/direct_inhibition.png binding EEF1A2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png IRF3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ down-regulates activity img/indirect_inhibition.png NfKb-p65/p50 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV CYTOKINE STORM, SARS-CoV FIBROSIS, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ down-regulates quantity img/direct_inhibition.png binding SMAD3/SMAD4 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV FIBROSIS
+ up-regulates activity img/indirect-activation.png JNK 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates activity img/indirect-activation.png p38 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Interferon-type-I 0.2
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION, SARS-CoV FIBROSIS, SARS-CoV STRESS GRANULES
+ up-regulates activity img/direct-activation.png AP1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FOS 0.2
Publications: 1 Organism: In Vitro