FAP: Notch

Pathway ID: SIGNOR-FapNOTCH

Description: The activation of NOTCH pathway inhibits adipogenesis by blocking the expression of PPARγ and C/EBPα. The same effect can be obtained by overexpressing the Notch target gene Hes-1 in 3T3-L1 cells. The Notch pathway regulates both adipogenesis and osteogenesis of mesenchymal stem cells in a complex manner by directly targeting the adipogenesis master regulator genes or by interacting with other signaling pathways.

Curated by: gcesareni

15 Seed Entities

Organism:
Name Primary ID
CEBPD P49716
gamma-secretase SIGNOR-C98
KLF5 Q13887
NR3C1 P04150
CREB1 P16220
rosiglitazone CHEBI:50122
PPARG P37231
RBPJ/NOTCH SIGNOR-C97
Adipogenesis SIGNOR-PH26
DLL1 O00548
CEBPB P17676
HES1 Q14469
CEBPA P49715
GATA2 P23769
NOTCH1 P46531