Summary

Name BAK1
Full Name Bcl-2 homologous antagonist/killer
Synonyms Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7 | BAK, BCL2L7, CDN1
Primary ID Q16611
Links - -
Type protein
Relations 26
Pathways Acute Myeloid Leukemia, MLL fusion protein in AML, Malignant Melanoma, Non-small-cell lung cancer (NSCLC)
Function Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation BAK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization AIFM1 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png DIABLO 0.519
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ENDOG 0.294
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BAK1 0.673
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML, Malignant Melanoma, Non-small-cell lung cancer (NSCLC)
+ up-regulates img/direct-activation.png binding BAK1 0.836
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png BAK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAK1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BAK1 0.744
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Malignant Melanoma
+ up-regulates img/direct-activation.png binding BAK1 0.689
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Malignant Melanoma, Non-small-cell lung cancer (NSCLC)
+ up-regulates img/direct-activation.png binding BAK1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML, Malignant Melanoma, Non-small-cell lung cancer (NSCLC)
+ up-regulates img/direct-activation.png binding BAK1 0.821
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization HTRA2 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML, Malignant Melanoma
+ up-regulates img/indirect-activation.png HTRA2 0.297
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BAK1 0.621
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates img/direct-activation.png relocalization CYCS 0.564
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization DIABLO 0.519
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CYCS 0.564
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BAK1 0.386
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BAK1 0.465
Publications: 1 Organism: Homo Sapiens