Summary

Name MOB1B
Full Name MOB kinase activator 1B
Synonyms Mob1 homolog 1A, Mob1A, Mob1B, Mps one binder kinase activator-like 1A | MOB4A, MOBKL1A
Primary ID Q7L9L4
Links - -
Type protein
Relations 13
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ STK3up-regulates img/direct-activation.png phosphorylation MOB1B 0.809
Publications: 4 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK4up-regulates img/direct-activation.png phosphorylation MOB1B 0.846
Publications: 4 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ PTPN5up-regulates activity img/direct-activation.png dephosphorylation MOB1B 0.2
Publications: 1 Organism: Homo Sapiens
+ MOB1Bup-regulates img/direct-activation.png binding LATS1 0.918
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates img/direct-activation.png phosphorylation MOB1B 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ MOB1Bup-regulates img/direct-activation.png binding LATS2 0.872
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ MOB1Bup-regulates img/direct-activation.png binding LATS1/2 0.918
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling