| + |
CSNK1E | down-regulates activity 
phosphorylation
|
DVL3 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276645 |
Ser280 |
DGGIYIGsIMKGGAV |
in vitro |
|
| pmid |
sentence |
| 24993822 |
Co-expression of CK1ϵ with FLAG-Dvl3 retards electrophoretic migration and induces phosphorylation-dependent shift of Dvl (PS-Dvl3). mutations of Ser-280 and Ser-311 prevent efficient activation of Wnt/β-catenin by Dvl3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276647 |
Ser311 |
EINFENMsNDDAVRV |
in vitro |
|
| pmid |
sentence |
| 24993822 |
Co-expression of CK1ϵ with FLAG-Dvl3 retards electrophoretic migration and induces phosphorylation-dependent shift of Dvl (PS-Dvl3). mutations of Ser-280 and Ser-311 prevent efficient activation of Wnt/β-catenin by Dvl3. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
FZD5 | up-regulates activity 
binding
|
DVL3 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258963 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL3 | up-regulates
binding
|
RAC1 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97409 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12533515 |
Wnt/fz activation of rac and rho is inhibited by rac-n17 and rho-n19, respectively (figs. _(figs.1d,1d, _d,5c,d;5c,d;habas et al. 2001), and requires different dvl domains wnt signaling induces complex formation between dvl and rac. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
binding
|
DVL3 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRRFIP2 | up-regulates
binding
|
DVL3 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133429 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15677333 |
In particular, a previously unrecognized activator, lrrfip2 (leucine-rich repeat in flightless interaction protein 2), was found that interacts with dvl to increase the cellular levels of _-catenin and activate _-catenin/lef/tcf-dependent transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NKD1 | down-regulates
binding
|
DVL3 |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15064403 |
Naked (nkd)1 and nkd2 are mammalian homologs of drosophila naked cuticle, which negatively regulates canonical wnt signaling by binding dishevelled. various reports using cell culture assays indicate that nkd-mediated wnt antagonism involves dvl degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20858476 |
Naked (nkd)1 and nkd2 are mammalian homologs of drosophila naked cuticle, which negatively regulates canonical wnt signaling by binding dishevelled. various reports using cell culture assays indicate that nkd-mediated wnt antagonism involves dvl degradation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
RYK | up-regulates
binding
|
DVL3 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD1 | up-regulates activity
binding
|
DVL3 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD4 | up-regulates activity
binding
|
DVL3 |
0.569 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096005 |
Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates
binding
|
DVL3 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199638 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co-receptors, syndecan 4 directly interacts with dvl during pcp 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL3 | up-regulates
binding
|
FRAT1 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97877 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12556519 |
These results indicate that cki epsilon-dependent phosphorylation of dvl enhances the formation of a complex of dvl-1 with frat-1 and that this complex leads to the activation of the wnt signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
KHSRP | down-regulates
binding
|
DVL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23800 |
|
|
Homo sapiens |
Neutrophil, Monocyte |
| pmid |
sentence |
| 2848118 |
Ksrp was shown to interact with the c-terminus of dvl3. We show that ksrp negatively regulates wnt/beta-catenin signaling at the level of post-transcriptional ctnnb1 (beta-catenin) mrna stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRRK2 | up-regulates
binding
|
DVL3 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202187 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23754980 |
Subsequent assays confirmed a direct interaction between the lrrk2 roccor domain and all three human dvl proteins, these data are consistent with a role for lrrk2 in the activation of canonical wnt signaling bringing dvl proteins to cellular membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL3 | up-regulates activity
|
PLCB1 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19279717 |
Dsh through PLC activates IP3, which leads to release of intracellular Ca2+, which in turn activates CamK11 and calcineurin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL3 | up-regulates
binding
|
CSNK1E |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10535959 |
Ckiepsilon was in a complex with axin and other downstream components of the wnt pathway, including dishevelled. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WDFY3 | down-regulates quantity by destabilization
relocalization
|
DVL3 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266793 |
|
|
Homo sapiens |
SH-SY5Y Cell |
| pmid |
sentence |
| 27008544 |
Our data taken together with the known role of ALFY in autophagy, demonstrate specific targeting and autophagy-mediated removal of DVL3 by hALFY. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL3 | up-regulates
binding
|
PIP5K1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180788 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18772438 |
Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates [ptdins (4,5)p2] through frizzled and dishevelled, the latter of which directly interacted with and activated pip5ki. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DVL3
- 
- 