Summary

Name MAP1LC3B
Full Name Microtubule-associated proteins 1A/1B light chain 3B
Synonyms Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B, Microtubule-associated protein 1 light chain 3 beta | MAP1ALC3
Primary ID Q9GZQ8
Links - -
Type protein
Relations 14
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:28017329). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP1LC3B 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP1LC3B 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP1LC3B 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MAP1LC3B 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding ATG3 0.828
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Autophagosome_formation 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP1LC3B 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP1LC3B 0.381
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus
+ up-regulates img/direct-activation.png cleavage MAP1LC3B 0.795
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP1LC3B 0.869
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP1LC3B 0.534
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NBR1 0.578
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SQSTM1 0.832
Publications: 2 Organism: Homo Sapiens