Summary

Name MAP1LC3B
Full Name Microtubule-associated proteins 1A/1B light chain 3B
Synonyms Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B, Microtubule-associated protein 1 light chain 3 beta | MAP1ALC3
Primary ID Q9GZQ8
Links - -
Type protein
Relations 9
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png unknown Autophagosome formation
Publications: 1 Organism: Homo Sapiens
Tissue: Fibroma Cell
+ up-regulates img/direct-activation.png cleavage MAP1LC3B 0.99
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SQSTM1
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP1LC3B 0.92
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NBR1 0.90
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ATG3 0.92
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP1LC3B 0.85
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MAP1LC3B 0.08
Publications: 1 Organism: Rattus Norvegicus