Summary
Name | ![]() View Modifications |
Full Name | Protein salvador homolog 1 |
Synonyms | 45 kDa WW domain protein, hWW45 | WW45 |
Primary ID | Q9H4B6 |
Links | ![]() ![]() ![]() |
Type | protein |
Relations | 10 |
Pathways | Hippo Signaling, YAP/TAZ regulation |
Function | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. |
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Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | STK25 | down-regulates activity ![]() |
SAV1 | 0.281 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | SAV1 | up-regulates activity ![]() |
STK3/4 | 0.895 |
Publications: | 2 | Organism: | Homo Sapiens | |
Pathways: | Hippo Signaling | |||
+ | STK4 | up-regulates ![]() |
SAV1 | 0.886 |
Publications: | 1 | Organism: | In Vitro | |
Pathways: | Hippo Signaling | |||
+ | SAV1 | up-regulates quantity by stabilization ![]() |
STK3 | 0.834 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | Hippo Signaling | |||
+ | SAV1 | up-regulates quantity by stabilization ![]() |
STK4 | 0.886 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | Hippo Signaling | |||
+ | SAV1 | up-regulates ![]() |
STK4 | 0.886 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | Hippo Signaling | |||
+ | STK3 | up-regulates ![]() |
SAV1 | 0.834 |
Publications: | 1 | Organism: | In Vitro | |
Pathways: | Hippo Signaling | |||
+ | STK3/4 | up-regulates activity ![]() |
SAV1 | 0.2 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | Hippo Signaling | |||
+ | SAV1 | up-regulates ![]() |
STK3 | 0.834 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | Hippo Signaling |