Summary

Name CD274
Full Name Programmed cell death 1 ligand 1
Synonyms PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1 | B7H1, PDCD1L1, PDCD1LG1, PDL1
Primary ID Q9NZQ7
Links - -
Type protein
Relations 15
Pathways Mitochondrial dynamics in T cell exhaustion
Function Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png glycosylation CD274 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png glycosylation CD274 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png glycosylation CD274 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination CD274 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination CD274 0.336
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png destabilization CD274 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CD274 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PDCD1 0.935
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png catalytic activity CD274 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png stabilization CD274 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD274 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png stabilization CD274 0.488
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png stabilization CD274 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CD274 0.485
Publications: 1 Organism: Homo Sapiens