Summary

Name MYOG
Full Name Myogenin
Synonyms Class C basic helix-loop-helix protein 3, bHLHc3, Myogenic factor 4, Myf-4 | BHLHC3, MYF4
Primary ID P15173
Links - -
Type protein
Relations 38
Pathways NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Pericyte: Myogenic transcriptional cascade, Rhabdomyosarcoma, Satellite: Calcium&myogenesis, Satellite: IFN gamma, Satellite: Myogenic transcriptional cascade, Satellite: miRNA network
Function Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding MYOG 0.349
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOG 0.432
Publications: 2
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOG 0.419
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.262
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding MYOG 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.432
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.364
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ITGA7 0.289
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/indirect-activation.png transcriptional regulation mir-133a2 0.4
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding FBXO32 0.532
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.249
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png transcriptional regulation MYOG 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DES 0.258
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYF6 0.404
Publications: 1
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOG 0.264
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MYOG 0.253
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.29
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.353
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding MYOG 0.539
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYOG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Publications: 1
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png binding SWI/SNF complex 0.329
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOG 0.481
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A 0.342
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG 0.46
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/indirect_inhibition.png MYOG 0.262
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png mir-133a1 0.4
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Myog/SWI/SNF complex 0.481
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding MYOG 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYOG 0.38
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png binding MYOG 0.383
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MYOG 0.382
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
Pathways:NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYOG 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/indirect_inhibition.png PAX7 0.513
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma