Summary

Name CDC42
Full Name Cell division control protein 42 homolog
Synonyms G25K GTP-binding protein
Primary ID P60953
Links - -
Type protein
Relations 59
Pathways Axon guidance, P38 Signaling and Myogenesis
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDC42 0.685
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.488
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.418
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PAK1 0.94
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png MAPK14 0.584
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding WAS 0.956
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor CDC42 0.653
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png gtpase-activating protein CDC42 0.619
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.474
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.566
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.539
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.534
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.364
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.403
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.462
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.508
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.703
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BAIAP2 0.855
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.727
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.437
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.468
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.487
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.603
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.725
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization USP6 0.367
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.705
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.557
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.66
Publications: 1
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.585
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.827
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.287
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.839
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CDC42 0.839
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDC42 0.697
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding CDC42BPA 0.783
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CDC42 0.805
Publications: 1
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.456
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.753
Publications: 1
+ up-regulates activity img/direct-activation.png binding PAK 0.94
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.369
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.496
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.331
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding GSK3B 0.389
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.769
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding WASL 0.917
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDC42 0.498
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PAK2 0.88
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding CDC42 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.736
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.377
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png NFATC1 0.282
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.902
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.658
Publications: 1 Organism: Homo Sapiens