| + |
INPP5B | down-regulates quantity 
chemical modification
|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277772 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. Rab5 effectors Inpp5b, OCRL and APPL1 localize to macropinocytic cups and vesicles, and are required for macropinosome sealing. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OCRL | down-regulates quantity
chemical modification
|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis. These observations raised the possibility that PtdIns(4,5)P2 depletion is in fact required for the completion of macropinocytosis or to prevent macropinosome back-fusion with the plasmalemma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | down-regulates
|
Early macropinosomes |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277774 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33722976 |
We report that Rab5 acts at the plasma membrane, downstream of ruffling, to promote macropinosome sealing and scission. Rab5 is recruited to plasmalemmal circular ruffles before macropinosome closure. The mammalian 5-phosphatases Inpp5b and OCRL, which can degrade PtdIns(4,5)P2, are both Rab5-associating effectors implicated in endocytosis and macropinocytosis. These observations raised the possibility that PtdIns(4,5)P2 depletion is in fact required for the completion of macropinocytosis or to prevent macropinosome back-fusion with the plasmalemma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | down-regulates activity
binding
|
RAB21 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19693279 |
It was demonstrated that wild-type Rab21 was transiently associated with macropinosomes. Rab21 was recruited to the macropinosomes after a decrease in PI(4,5)P(2) and PI(3,4,5)P(3) levels. Although Rab21 was largely colocalized with Rab5, the recruitment of Rab21 to the macropinosomes lagged a minute behind that of Rab5, and preceded that of Rab7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | up-regulates quantity 
precursor of
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
PLCG2 | down-regulates quantity
chemical modification
|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | up-regulates quantity
precursor of
|
1D-myo-inositol 1,4,5-trisphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23000145 |
Upon stimulation with various immune receptors, PLCγ2 cleaves the membrane-bound phospholipid phosphatidyl inositol-4, 5-biphosphate (PIP2) into the second messenger molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | B-cell activation |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | form complex 
binding
|
AP-2/clathrin vescicle |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24789820 |
AP2 adaptor complexes, associated at the membrane with PtdIns(4,5)P2 (PIP2), recruit clathin triskelions to initiate lattice assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | form complex
binding
|
AP-3/clathrin vescicle |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23103167 |
Clathrin-coated pits and vesicles are diffraction-limited objects with typical diameters ranging between 75 and 130 nm. The smaller ∼75 nm coats contain at least 36 copies of clathrin, a heterohexameric protein of three heavy chains and three light chains, and about half that number of copies of the heterotetrameric AP adaptor complex | Intracellular clathrin-coated vesicles contain AP1 or AP3 adaptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate