Summary

Name ADAM10
Full Name Disintegrin and metalloproteinase domain-containing protein 10
Synonyms ADAM 10, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease | KUZ, MADM
Primary ID O14672
Links - -
Type protein
Relations 9
Function Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage NOTCH
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional activation ADAM10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage BTC
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage EGF
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage ERBB2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CDH1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CD44
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ADAM10 0.14
Publications: 1 Organism: Homo Sapiens