Summary

Name KLF4
Full Name Krueppel-like factor 4
Synonyms Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor | EZF, GKLF
Primary ID O43474
Links - -
Type protein
Relations 23
Pathways Macrophage: TNF alpha transcriptional regulation, Myoblast: GH-mediated fusion
Function Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png ubiquitination KLF4 0.286
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation KLF4 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding KLF4 0.281
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SOD1 0.292
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png KLF4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png KLF4 0.466
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF4 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TNF 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KLF4 0.374
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding SRF 0.369
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates activity img/direct-activation.png binding PBX1 0.477
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MYOCD 0.466
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/indirect-activation.png STAT6 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TP53 0.562
Publications: 1
+ up-regulates activity img/direct-activation.png binding KLF4 0.685
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF4 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NPNT 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KLF4 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLF4 0.346
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MEIS2 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png transcriptional regulation THBD 0.303
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA8 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KLF4 0.366
Publications: 1 Organism: Homo Sapiens