EGFR Signaling

Pathway ID: SIGNOR-EGFView in NDEx

Description: The epidermal growth factor receptor (EGFR) signaling pathway regulates growth, survival, proliferation, and differentiation. The binding of extracellular ligands (EGF) induces homo and heterodimerization, transphosphorylation and activation of four ErbB family receptors: EGFR (ErbB1), ErbB2, ErbB3, and ErbB4. These events trigger a cascade of activation of downstream pathways that include, principally, the MAPK, Akt and JNK pathways, culminating in DNA synthesis and cell proliferation.

Curated by: Theodora Pavlidou

32 Seed Entities

Organism:
Name Primary ID
MEK1/2 SIGNOR-PF25
JUN P05412
GRB2 P62993
Cell_growth SIGNOR-PH33
MAP3K1 Q13233
ELK1 P19419
GAB1 Q13480
EGF P01133
MYC P01106
STAT3 P40763
NCK1 P16333
PDPK1 O15530
ERRFI1 Q9UJM3
PTPN11 Q06124
PIK3CA P42336
CBLB Q13191
JAK2 O60674
BRAF P15056
PIP3 CHEBI:16618
mTORC1 SIGNOR-C3
SHC1 P29353
MAP2K4 P45985
FOS P01100
Proliferation SIGNOR-PH4
ERK1/2 SIGNOR-PF1
SRC P12931
MAPK8 P45983
PAK1 Q13153
HRAS P01112
SOS1 Q07889
EGFR P00533
AKT SIGNOR-PF24