| + |
HDAC1 | up-regulates 
deacetylation
|
FLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202689 |
Lys380 |
PTESSMYkYPSDISY |
Homo sapiens |
|
| pmid |
sentence |
| 24058639 |
Hdac1 interacts with fli1 and mediates its deacetylation / our previous studies have shown that pcaf-dependent acetylation of fli1 at lysine 380 decreases its protein stability / p300 promotes the interaction of fli1 with hdac1 and increases the dna binding ability of fli1 through deacetylation of lysine 380 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCD | down-regulates 
phosphorylation
|
FLI1 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202693 |
Thr312 |
TNGEFKMtDPDEVAR |
Homo sapiens |
|
| pmid |
sentence |
| 24058639 |
After tgf-_ stimulation, fli1 phosphorylation by protein kinase c-_ induces disassembly of this transcription repressor complex and the acetylation of fli1 by pcaf, leading to the loss of fli1 dna binding. / phosphorylation of fli1 at threonine 312 decreases its interactions with p300 and hdac1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172113 |
Thr312 |
TNGEFKMtDPDEVAR |
Homo sapiens |
|
| pmid |
sentence |
| 21321929 |
We have previously demonstrated that in response to transforming growth factor _ (tgf_), fli-1 activity is repressed through a series of sequential posttranslational modifications, consisting of protein kinase c_ (pkc_)-induced thr312 phosphorylation, acetylation by p300/creb binding protein-associated factor, and detachment from the collagen promoter. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EP300 | up-regulates
binding
|
FLI1 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24058639 |
P300 promotes the interaction of fli1 with hdac1 and increases the dna binding ability of fli1 through deacetylation of lysine 380 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | up-regulates quantity by expression 
transcriptional regulation
|
ERG |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253921 |
|
|
Homo sapiens |
T-cell Acute Lymphoblastic Leukemia Cell |
| pmid |
sentence |
| 21536859 |
We further demonstrate that ERG expression in primary human T-ALL cells is mediated by the binding of other T-cell oncogenes SCL/TAL1, LMO2, and LYL1 in concert with ERG, FLI1, and GATA3 to the ERG +85 enhancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBP/p300 | down-regulates
acetylation
|
FLI1 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172109 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21321929 |
We have previously demonstrated that in response to transforming growth factor _ (tgf_), fli-1 activity is repressed through a series of sequential posttranslational modifications, consisting of protein kinase c_ (pkc_)-induced thr312 phosphorylation, acetylation by p300/creb binding protein-associated factor, and detachment from the collagen promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | down-regulates quantity by repression 
transcriptional regulation
|
COL1A2 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202685 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24058639 |
Fli1 functions as a potent transcriptional repressor of the col1a2 gene |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | up-regulates quantity by expression
transcriptional regulation
|
GP9 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254160 |
|
|
Homo sapiens |
MEG-01 Cell |
| pmid |
sentence |
| 15466856 |
Both Fli-1 and GATA-1 are required for formation of an active transcriptional complex on the C-MPL and GPIX promoters in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF1 | down-regulates activity
binding
|
FLI1 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256046 |
|
|
Mus musculus |
MEL Cell |
| pmid |
sentence |
| 12556498 |
The present study also shows that EKLF itself inhibits FLI-1 activity. As suggested above for the inhibition of EKLF activity, the inhibition of FLI-1 activity most probably involves the indirect recruitment of EKLF to FLI-1 target promoters by protein-protein interaction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
ETV2 | up-regulates quantity by expression
transcriptional regulation
|
FLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203272 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24727028 |
We have identified a novel positive feed-forward regulatory loop in which etv2 activates expression of genes involved in vasculogenesis, including fli1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | down-regulates activity
binding
|
KLF1 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256044 |
|
|
Mus musculus |
MEL Cell |
| pmid |
sentence |
| 12556498 |
FLI-1 represses the transcriptional activity of EKLF.Our data indicate that the ETS domain of FLI-1 is absolutely required to inhibit EKLF activity. Since the FLI-1 ETS domain interacts with the DNA binding domain of EKLF, one possibility could be that FLI-1 inhibits the binding of EKLF to its DNA targets |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
FLI1 | down-regulates quantity by repression
transcriptional regulation
|
ANKRD26 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266070 |
|
|
Homo sapiens |
Megakaryocyte |
| pmid |
sentence |
| 24430186 |
In healthy individual, RUNX1/FLI1 complex negatively regulates ANKRD26 gene expression in MKs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | down-regulates quantity by repression
transcriptional regulation
|
HOXA10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254471 |
|
|
Homo sapiens |
Megakaryocyte Cell Line |
| pmid |
sentence |
| 17688409 |
Transcription factors GATA-1 and Fli-1 regulate human HOXA10 expression in megakaryocytic cells. Mutation of the GATA-1 and the Ets-1 motifs amplified the expression of HOXA10 in HEL and K562 cells, confirming the importance of these cis-acting elements in regulating HOXA10 expression in megakaryocytic cells. Chromatin immunoprecipitation (ChIP) and chloramphenicol acetyl transferase (CAT) assays confirm that HOXA11 binds to the putative binding site, resulting in repression of HOXA10 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPI1 | up-regulates quantity by expression
transcriptional regulation
|
FLI1 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256054 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10523830 |
Our results suggest that Spi-1 and GATA-1 might play a key role in the regulation of Fli-1. Most notably, we observed that the GATA/EBS dual element near the Fli-1 CAP sites had an enhancer activity in HEL cells. Spi-1 and GATA-1 were both found to bind to this sequence and hence both factors could represent potential regulators of Fli-1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
FLI1 | up-regulates quantity by expression
transcriptional regulation
|
GP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254157 |
|
|
Homo sapiens |
Megakaryocyte Cell Line |
| pmid |
sentence |
| 12359731 |
Deletion analyses and site-directed mutagenesis identified Sp1(227), GATA(177), and Ets(48) sites as essential for GPVI expression. We show that transcription factors GATA-1, Fli-1, and Sp1 can bind to and activate this promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | up-regulates activity
binding
|
GATA1 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256045 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 12556498 |
On the other hand, our data demonstrate that FLI-1 also interacts with GATA-1. However, FLI-1 does not repress but enhances GATA-1 activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
GATA1 | up-regulates quantity by expression
transcriptional regulation
|
FLI1 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10523830 |
Our results suggest that Spi-1 and GATA-1 might play a key role in the regulation of Fli-1. Most notably, we observed that the GATA/EBS dual element near the Fli-1 CAP sites had an enhancer activity in HEL cells. Spi-1 and GATA-1 were both found to bind to this sequence and hence both factors could represent potential regulators of Fli-1 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
KDM6A | down-regulates quantity by repression
transcriptional regulation
|
FLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260034 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29736013 |
Our findings reveal a dual role for UTX in suppressing acute myeloid leukaemia via repression of oncogenic ETS and upregulation of tumor suppressive GATA programs. several ETS transcription factors, including Elf4, Etv6, Erg, Fli1, Ets2, Spi1 and Elk3 were upregulated immediately after Utx loss in the preleukaemic phase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | up-regulates
|
Megakaryocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256087 |
|
|
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 28052010 |
The ETS-related transcription factor Fli-1 affects many developmental programs including erythroid and megakaryocytic differentiation, and is frequently de-regulated in cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
FLI1 | up-regulates quantity by expression
transcriptional regulation
|
MPL |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254163 |
|
|
Homo sapiens |
MEG-01 Cell |
| pmid |
sentence |
| 15466856 |
Both Fli-1 and GATA-1 are required for formation of an active transcriptional complex on the C-MPL and GPIX promoters in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLI1 | up-regulates activity
|
Monocyte_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259972 |
|
|
Mus musculus |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 23320737 |
The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
FLI1 | up-regulates
transcriptional regulation
|
IL10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254516 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20879862 |
In terms of cytokine expression, increased FLI-1 levels specifically enhanced IL-10 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FLI1
- 
- 