Summary

Name FLI1
Full Name Friend leukemia integration 1 transcription factor
Synonyms Proto-oncogene Fli-1, Transcription factor ERGB
Primary ID Q01543
Links - -
Type protein
Relations 19
Pathways TFs in AML
Function Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png deacetylation FLI1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FLI1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP9 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding KLF1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:TFs in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HOXA10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding FLI1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:TFs in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation FLI1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:TFs in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation FLI1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:TFs in AML
+ up-regulates img/indirect-activation.png Megakaryocyte differentiation 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:TFs in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FLI1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png acetylation FLI1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FLI1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COL1A2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GATA1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:TFs in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MPL 0.14
Publications: 1 Organism: Homo Sapiens