Summary

Name CBLB
Full Name E3 ubiquitin-protein ligase CBL-B
Synonyms Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56, SH3-binding protein CBL-B, Signal transduction protein CBL-B | RNF56
Primary ID Q13191
Links - -
Type protein
Relations 4
Pathways EGFR
Function E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding NCK1 0.62
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates activity img/direct-activation.png binding GRB2 0.44
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates activity img/direct_inhibition.png ubiquitination EGFR 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates img/direct_inhibition.png binding CBLB 0.54
Publications: 1 Organism: Homo Sapiens