| + |
WNT7A | up-regulates activity 
binding
|
Frizzled |
0.759 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253130 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
Frizzled | up-regulates
binding
|
DVL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255892 |
|
|
|
|
| pmid |
sentence |
| 19279717 |
After binding of Wnt to the receptor complex, the signal is transduced to cytoplasmic phosphoprotein Dishevelled (Dsh/Dvl), and studies have uncovered that Dsh can directly interact with Fz |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255891 |
|
|
|
|
| pmid |
sentence |
| 19279717 |
Wnt signaling is transduced through Fz independent of LRP5/6 leading to the activation of Dsh. |
|
| Publications: |
2 |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
WNT3A | up-regulates activity
binding
|
Frizzled |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255650 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21078818 |
Ligands such as wnt1, wnt3a, and wnt8 couple the seventransmembrane domain receptor frizzled (fzd) and the single-membrane-spanning low-density receptor-related protein 5/6 (lrp5/6) to activate wnt Beta-catenin signaling. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
Frizzled | up-regulates activity 
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255652 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
[…] we suggest that Wnt1, Wnt3a and Wnt5a result in the accumulation of Act-β-Cat |
|
| Publications: |
1 |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
WNT5A | up-regulates activity
binding
|
Frizzled |
0.828 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255651 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
WNT11 | up-regulates activity
binding
|
Frizzled |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253127 |
|
|
Homo sapiens |
Lung Cancer Cell, Melanoma Cell |
| pmid |
sentence |
| 16273260 |
Human wnt5a, wnt5b and wnt11 are non-canonical wnt ligands transducing pcp signals through fzd3 or fzd6 receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
Frizzled | up-regulates activity
binding
|
DVL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
Wnt | up-regulates activity
binding
|
Frizzled |
0.834 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256173 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23290138 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
WNT1 | up-regulates activity
binding
|
Frizzled |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253126 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16936075 |
Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz) receptors (Fz1 and/or Fz6) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255649 |
|
|
|
|
| pmid |
sentence |
| 18697834 |
Wnt1, Wnt3a and Wnt5a all induced a statistically greater degree of proliferation than control cells |
|
| Publications: |
2 |
Organism: |
Mus Musculus, |
| Tissue: |
Muscle |
| Pathways: | WNT Signaling, WNT Signaling and Myogenesis |
| + |
Frizzled | up-regulates activity
binding
|
GNAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253125 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22944199 |
Wnt7a binding to fzd7 activates pi3k through a g protein alpha s- dependent mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
| + |
Frizzled | up-regulates
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255687 |
|
|
|
|
| pmid |
sentence |
| 23209147 |
The Wnt–FZD–LRP5/6 trimeric complex recruits Dishevelled (DVL) and Axin through the intracellular domains of FZD and LRP5/6, resulting in inhibition of β-catenin phosphorylation and thus ensuing β-catenin stabilization. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis |
3.0
Frizzled