Summary

Name FZD3
Full Name Frizzled-3
Synonyms Fz-3, hFz3
Primary ID Q9NPG1
Links - -
Type protein
Relations 33
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including

Viewer

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CXCL1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNB3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAQ 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD3 0.23
Publications: 3 Organism: Homo Sapiens
Tissue: Endothelium
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NLK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD3 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding GNA13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RHOA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNGT1 0.14
Publications: 1 Organism: Homo Sapiens