Summary

Name CASP9
Full Name Caspase-9
Synonyms CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6 | MCH6
Primary ID P55211
Links - -
Type protein
Relations 59
Pathways COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; FUNCTION

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage CASP9 0.617
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png cleavage CASP9 0.617
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.355
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.768
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:Parkinson
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.506
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.768
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.494
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.554
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.354
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.447
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.454
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.436
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CASP9 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CASP9 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CASP9 0.386
Publications: 1
+ up-regulates img/indirect-activation.png CASP9 0.727
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ up-regulates activity img/indirect-activation.png CASP9 0.59
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding Apoptosome 0.915
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding CASP9 0.749
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CASP9 0.709
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CASP9 0.92
Publications: 3 Organism: In Vitro, Homo Sapiens
Pathways:Death Receptor Signaling, Inhibition of Apoptosis, Parkinson
+ form complex img/form-complex.png binding Caspase 9 complex 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png binding CASP9 0.474
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP9 0.378
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CASP9 0.59
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates img/direct_inhibition.png binding CASP9 0.521
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CASP9 0.953
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ up-regulates activity img/indirect-activation.png CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASP9 0.876
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis
+ up-regulates activity img/indirect-activation.png CASP9 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates activity img/indirect-activation.png CASP9 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png binding CASP9 0.953
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 1
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis
+ up-regulates activity img/direct-activation.png binding CASP9 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP9 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.617
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS
+ down-regulates activity img/direct_inhibition.png polyubiquitination CASP9 0.2
Publications: 1 Organism: Homo Sapiens