| + |
CASP3 | up-regulates activity 
cleavage
|
CASP9 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133264 |
Asp330 |
LRTFDQLdAISSLPT |
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 15657060 |
In turn, casp3 directs feedback cleavage of casp9 at asp-330 to generate p37 and p10 subunits. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90397 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Active caspase-3 itself is able to process its upstream , caspase-8 and caspase-9, establishing a self-amplifying loop of caspase activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS |
| + |
Caspase 3 complex | up-regulates activity
cleavage
|
CASP9 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256440 |
Asp330 |
LRTFDQLdAISSLPT |
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 15657060 |
In turn, casp3 directs feedback cleavage of casp9 at asp-330 to generate p37 and p10 subunits. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Active caspase-3 itself is able to process its upstream , caspase-8 and caspase-9, establishing a self-amplifying loop of caspase activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKCZ | down-regulates 
phosphorylation
|
CASP9 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141629 |
Ser144 |
GDVGALEsLRGNADL |
Homo sapiens |
|
| pmid |
sentence |
| 16287866 |
Inhibitor sensitivity and interactions with caspase 9 indicate that the predominant kinase that targets ser144 is the atypical protein kinase c isoform zeta (pkczeta). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates
phosphorylation
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133880 |
Ser183 |
GLRTRTGsNIDCEKL |
Homo sapiens |
|
| pmid |
sentence |
| 15703181 |
We show that protein kinase a inhibits activation of caspase-9 and caspase-3 downstream of cytochrome c in xenopus egg extracts and in a human cell-free system. Protein kinase a directly phosphorylates human caspase-9 at serines 99, 183, and 195. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133884 |
Ser195 |
EKLRRRFsSLHFMVE |
Homo sapiens |
|
| pmid |
sentence |
| 15703181 |
We show that protein kinase a inhibits activation of caspase-9 and caspase-3 downstream of cytochrome c in xenopus egg extracts and in a human cell-free system. Protein kinase a directly phosphorylates human caspase-9 at serines 99, 183, and 195. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133888 |
Ser99 |
NRQAAKLsKPTLENL |
Homo sapiens |
|
| pmid |
sentence |
| 15703181 |
We show that protein kinase a inhibits activation of caspase-9 and caspase-3 downstream of cytochrome c in xenopus egg extracts and in a human cell-free system. Protein kinase a directly phosphorylates human caspase-9 at serines 99, 183, and 195. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
AKT | down-regulates activity
phosphorylation
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251473 |
Ser196 |
KLRRRFSsLHFMVEV |
in vitro |
|
| pmid |
sentence |
| 9812896 |
Akt phosphorylated recombinant Casp9 in vitro on serine-196 and inhibited its protease activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71480 |
Ser196 |
KLRRRFSsLHFMVEV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10529400 |
Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9BAD phosphorylation by Akt is an essential step for growth factor-mediated inhibition of caspase activation |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Inhibition of Apoptosis, SARS-COV APOPTOSIS |
| + |
AKT1 | down-regulates activity
phosphorylation
|
CASP9 |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252581 |
Ser196 |
KLRRRFSsLHFMVEV |
in vitro |
|
| pmid |
sentence |
| 9812896 |
Akt phosphorylated recombinant casp9 in vitro on serine-196 and inhibited its protease activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252585 |
Ser196 |
KLRRRFSsLHFMVEV |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10529400 |
Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9BAD phosphorylation by Akt is an essential step for growth factor-mediated inhibition of caspase activation |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| Pathways: | Parkinson |
| + |
AKT1 | down-regulates
phosphorylation
|
CASP9 |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252472 |
Ser196 |
KLRRRFSsLHFMVEV |
Homo sapiens |
|
| pmid |
sentence |
| 15004527 |
Akt phosphorylated recombinant casp9 in vitro on serine-196 and inhibited its protease activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Parkinson |
| + |
AKT2 | down-regulates
phosphorylation
|
CASP9 |
0.522 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-61561 |
Ser196 |
KLRRRFSsLHFMVEV |
Homo sapiens |
|
| pmid |
sentence |
| 9812896 |
Akt phosphorylated recombinant casp9 in vitro on serine-196 and inhibited its protease activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123243 |
Ser196 |
KLRRRFSsLHFMVEV |
Homo sapiens |
|
| pmid |
sentence |
| 15004527 |
Akt phosphorylated recombinant casp9 in vitro on serine-196 and inhibited its protease activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT3 | down-regulates
phosphorylation
|
CASP9 |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-61565 |
Ser196 |
KLRRRFSsLHFMVEV |
Homo sapiens |
|
| pmid |
sentence |
| 9812896 |
Akt phosphorylated recombinant casp9 in vitro on serine-196 and inhibited its protease activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K2 | down-regulates activity
phosphorylation
|
CASP9 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249386 |
Thr125 |
PEVLRPEtPRPVDIG |
|
|
| pmid |
sentence |
| 12792650 |
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK|The opposing protein kinase activity is overcome by treatment with the broad-specificity kinase inhibitor staurosporine or with inhibitors of MEK1/2 |
|
| Publications: |
1 |
| + |
CyclinB/CDK1 | down-regulates
phosphorylation
|
CASP9 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216876 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 16287866 |
Here, we show that the apoptotic initiator protease caspase-9 is regulated during the cell cycle through periodic phosphorylation at an inhibitory site, thr125. This site is phosphorylated by cdk1/cyclin b1 during mitosis and in response to microtubule poisons that arrest cells at this stage of the cell cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216884 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 17466630 |
Here, we show that the apoptotic initiator protease caspase-9 is regulated during the cell cycle through periodic phosphorylation at an inhibitory site, thr125. This site is phosphorylated by cdk1/cyclin b1 during mitosis and in response to microtubule poisons that arrest cells at this stage of the cell cycle. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | down-regulates activity
phosphorylation
|
CASP9 |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101544 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 12792650 |
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148616 |
Thr125 |
PEVLRPEtPRPVDIG |
Mus musculus |
T-lymphocyte |
| pmid |
sentence |
| 16888006 |
ERK/MAPK phosphorylates caspase-9 at Thr(125), and this phosphorylation is crucial for caspase-9 inhibition |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
DYRK1A | down-regulates activity
phosphorylation
|
CASP9 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279326 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 19016842 |
Depletion of DYRK1A from human cells by short interfering RNA inhibits the basal phosphorylation of caspase 9 at an inhibitory site, Thr125. DYRK1A-dependent phosphorylation of Thr125 is also blocked by harmine, confirming the use of this beta-carboline alkaloid as a potent inhibitor of DYRK1A in cells.|When co-expressed in cells, DYRK1A interacts with caspase 9, strongly induces Thr125 phosphorylation and inhibits caspase 9 auto-processing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CA | up-regulates activity
dephosphorylation
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248565 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 16888006 |
ERK/MAPK phosphorylates caspase-9 at Thr(125), and this phosphorylation is crucial for caspase-9 inhibition. Until now, the phosphatase responsible for Thr(125) dephosphorylation has not been described. Here, we demonstrate that in IL-2-proliferating cells, phosphorylated serine/threonine phosphatase type 1alpha (PP1alpha) associates with phosphorylated caspase-9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K1 | down-regulates activity
phosphorylation
|
CASP9 |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249385 |
Thr125 |
PEVLRPEtPRPVDIG |
|
|
| pmid |
sentence |
| 12792650 |
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK|The opposing protein kinase activity is overcome by treatment with the broad-specificity kinase inhibitor staurosporine or with inhibitors of MEK1/2 |
|
| Publications: |
1 |
| + |
MAPK3 | down-regulates activity
phosphorylation
|
CASP9 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101548 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 12792650 |
Inhibition of caspase-9 through phosphorylation at thr 125 by erk mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CA | up-regulates
dephosphorylation
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195992 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 22311969 |
Pp1 dephosphorylated thr125 site of caspase-9 and activated caspase-9 to mediate il-2 deprivation-induced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates
phosphorylation
|
CASP9 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141621 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 16287866 |
Here, we show that the apoptotic initiator protease caspase-9 is regulated during the cell cycle through periodic phosphorylation at an inhibitory site, thr125. This site is phosphorylated by cdk1/cyclin b1 during mitosis and in response to microtubule poisons that arrest cells at this stage of the cell cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154626 |
Thr125 |
PEVLRPEtPRPVDIG |
Homo sapiens |
|
| pmid |
sentence |
| 17466630 |
Here, we show that the apoptotic initiator protease caspase-9 is regulated during the cell cycle through periodic phosphorylation at an inhibitory site, thr125. This site is phosphorylated by cdk1/cyclin b1 during mitosis and in response to microtubule poisons that arrest cells at this stage of the cell cycle. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
CASP9 |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133260 |
Tyr153 |
RGNADLAyILSMEPC |
Homo sapiens |
|
| pmid |
sentence |
| 15657060 |
C-abl phosphorylates casp9 on tyr-153 in vitro and in vivo in response to dna damage.The Present results demonstrate that c-abl binds directly to casp9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates activity
phosphorylation
|
CASP9 |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260792 |
Tyr153 |
LAYILSMePCGHCLI |
Homo sapiens |
|
| pmid |
sentence |
| 15657060 |
We show that ABL1 phosphorylates caspase-9 on Tyr-153 in vitro and in cells treated with DNA damaging agents. ! Moreover, inhibition of ABL1 with STI571 blocked DNA damage-induced autoprocessing of caspase-9 to the p35 subunit and activation of caspase-3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
CASP9 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272998 |
Tyr251 |
LQFPGAVyGTDGCPV |
|
|
| pmid |
sentence |
| 29844931 |
As a result, we established that Src was able to directly phosphorylate caspase-9 at tyrosine 251, leading to elevated caspase-9 activity. |
|
| Publications: |
1 |
| + |
CASP8 | up-regulates activity 
|
CASP9 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81811 |
|
|
in vitro |
|
| pmid |
sentence |
| 10988287 |
One indirect means through which caspase-8 might regulate caspase-9 activation is through a bcl-2-regulated pathway. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
MYCT1 | up-regulates activity
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261943 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30283340 |
Herein, we observed that overexpression of MYCT1 induced apoptosis in HL-60 and KG-1a cells, and upregulated Bax, downregulated Bcl-2, and enhanced cleavage of caspase-3 and -9. Similar proapoptotic role of MYCT1 was also found in the AML cell xenografts. These results suggest that MYCT1 affects AML cell apoptosis by modulating the endogenous apoptotic pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP12 | up-regulates
cleavage
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90318 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 12097332 |
Caspase-12 specifically cleaves and activates procaspase-9 in cytosolic extracts. Results suggest that caspase-12 can activate caspase-9 without involvement of cytochromec. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYCS | up-regulates activity
binding
|
CASP9 |
0.88 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53585 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9390557 |
Caspase-9 and apaf-1 bind to each other via their respective nh2-terminal ced-3 homologous domains in the presence of cytochrome c and datp, an event that leads to caspase-9 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS |
| + |
XIAP | down-regulates quantity by destabilization
binding
|
CASP9 |
0.92 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56484 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9545235 |
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspasesThese findings demonstrate that IAPs can suppress different apoptotic pathways by inhibiting distinct caspases and identify pro-caspase-9 as a new target for IAP-mediated inhibition of apoptosis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98988 |
|
|
in vitro |
|
| pmid |
sentence |
| 12620238 |
This paper reports the crystal structure of caspase-9 in an inhibitory complex with the third baculoviral iap repeat (bir3) of xiap at 2.4 a resolution. X-linked inhibitor-of-apoptosis protein (xiap) interacts with caspase-9 and inhibits its activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105702 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11242052 |
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | Death Receptor Signaling, Inhibition of Apoptosis, Parkinson |
| + |
ANP32A | up-regulates activity
binding
|
CASP9 |
0.282 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259082 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12522243 |
PHAP proteins promoted caspase-9 activation after apoptosome formation, whereas ProT negatively regulated caspase-9 activation by inhibiting apoptosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DIABLO | up-regulates
|
CASP9 |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80215 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10929711 |
Smac promotes caspase-9 activation by binding to inhibitor of apoptosis proteins, iaps, and removing their inhibitory activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Death Receptor Signaling |
| + |
CASP9 | up-regulates activity
cleavage
|
CASP3 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53582 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9390557 |
Activated caspase-9 in turn cleaves and activates caspase-3. Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133267 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15657060 |
Following autoprocessing in the apoptosome, caspase-9 cleaves and activates caspase-3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS |
| + |
ERK1/2 | down-regulates activity
phosphorylation
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270184 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12792650 |
Inhibition of caspase-9 through phosphorylation at thr 125 by erk mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Inhibition of Apoptosis |
| + |
HECTD3 | down-regulates activity
polyubiquitination
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272329 |
|
|
Homo sapiens |
KYSE-30 Cell |
| pmid |
sentence |
| 28716524 |
HECTD3 binds and ubiquitinates caspase-9.HECTD3 inhibits caspase-9 oligomerization and association with Apaf-1. HECTD3 suppressing caspase-9 activation is dependent on T157 phosphorylation by ERK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTMA | down-regulates
binding
|
CASP9 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259079 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12522243 |
PHAP proteins promoted caspase-9 activation after apoptosome formation, whereas ProT negatively regulated caspase-9 activation by inhibiting apoptosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | down-regulates activity
phosphorylation
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270084 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12792650 |
Inhibition of caspase-9 through phosphorylation at thr 125 by erk mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 8 complex | up-regulates activity
|
CASP9 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256479 |
|
|
in vitro |
|
| pmid |
sentence |
| 10988287 |
One indirect means through which caspase-8 might regulate caspase-9 activation is through a bcl-2-regulated pathway. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MEK1/2 | down-regulates activity
phosphorylation
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270222 |
|
|
|
|
| pmid |
sentence |
| 12792650 |
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK|The opposing protein kinase activity is overcome by treatment with the broad-specificity kinase inhibitor staurosporine or with inhibitors of MEK1/2 |
|
| Publications: |
1 |
| Pathways: | COVID-19 Causal Network, Inhibition of Apoptosis |
| + |
APAF1 | up-regulates activity
binding
|
CASP9 |
0.953 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53576 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9390557 |
Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15829969 |
During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 . |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
NAIP | down-regulates
binding
|
CASP9 |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127193 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15280366 |
These results demonstrate that naip is distinct from the other iaps, both in demonstrating a ligand-dependent caspase-9 interaction and in demonstrating a distinct mechanism of inhibition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates
binding
|
CASP9 |
0.756 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9545235 |
Xiap, birc2 and birc3 were shown to bind pro-casp9. Iaps may suppress casp9 by direct auto-activation of pro-caspase-11 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL2L1 | down-regulates activity
binding
|
CASP9 |
0.693 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56402 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9539746 |
Bcl2l1 associates with casp9 and apaf-1 in mammalian cells.Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
BIRC5 | down-regulates
binding
|
CASP9 |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84065 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11069302 |
Survivin (an inhibitor of apoptosis) phosphorylation on thr34 may regulate apoptosis at cell division via an interaction with caspase-9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP9 | form complex 
binding
|
Apoptosome |
0.916 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256429 |
|
|
in vitro |
|
| pmid |
sentence |
| 10206961 |
APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex. Such a complex can be isolated using gel filtration chromatography and is by itself sufficient to recruit and activate procaspase-9. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CARD8 | down-regulates
binding
|
CASP9 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16678772 |
Tucan is a recently identified card-containing protein that can complex with caspase-9 and prevent cytochrome c-induced caspase activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
M | up-regulates activity
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260202 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25271362 |
Taken together, our results demonstrated that expression of M-protein causes activation of both caspases 8 and 9 via the PKB/Akt signalling cascades. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
| + |
3a | up-regulates activity
|
CASP9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260213 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18632968 |
Thus, caspase-9 activation and cytochrome c release in cells expressing the 3a protein indicated that this viral protein also activates the intrinsic pathway of apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
| + |
CASP9 | form complex
binding
|
Caspase 9 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256397 |
|
|
|
|
| pmid |
sentence |
| 29500231 |
The caspase-9 CARD has been thought to be principally involved in recruitment to the apoptosome, but its roles outside this interaction have yet to be uncovered. In this work, we show that the CARD is involved in physical interactions with the catalytic core of caspase-9 in the absence of the apoptosome; this interaction requires a properly formed caspase-9 active site. |
|
| Publications: |
1 |
| + |
APAF1 | up-regulates
binding
|
CASP9 |
0.953 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53579 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9390557 |
During apoptosis, apaf-1 binds to cytochrome c and in the presence of atp/datp forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 .in particular, caspase-9 is recruited and activated by apaf-1 .casp9 and apaf-1 bind to each other via their respective nh2-terminal ced-3 homologous domains in the presence of cycs and datp, an event that leads to casp9 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
4.0
CASP9
- 
- 